Expression of transglutaminase 1 in human hair follicles, sebaceous glands and sweat glands

The British Journal of Dermatology
K YonedaS Y Kim

Abstract

To explore the function of the enzyme transglutaminase 1 (TGase 1), its distribution was analysed by immunofluorescence microscopy, postembedding immunoelectron microscopy and in situ hybridization. TGase 1 was expressed in the outer root sheath (ORS) cells in the distal portion of the isthmus and infundibulum of human hair follicles. In the level of the proximal and middle portion of the isthmus, TGase 1 was observed in the keratinized area of the inner root sheath (IRS) and ORS cells. In the bulbar and suprabulbar portions, TGase 1 was present in the ORS and IRS cells. The cortex and medulla cells in these regions also contained TGase 1. A high level of fluorescence was observed at the cuticle of the cortex. Sebaceous and sweat gland cells contained abundant TGase 1. Possible functions of TGase 1 in these epidermal appendages are discussed.

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Citations

Jun 26, 2001·The British Journal of Dermatology·I BarajonP Castano
Jun 20, 2002·The British Journal of Dermatology·M AkiyamaH Shimizu
Nov 6, 1998·The Journal of Investigative Dermatology·K KizawaH Uchiwa
Aug 25, 2005·The Journal of Investigative Dermatology·Sébastien ThibautBruno A Bernard
Jan 27, 2012·The Journal of Investigative Dermatology·Kozo YonedaRichard B Presland
Aug 23, 2008·The Journal of Investigative Dermatology·Sébastien ThibautBruno A Bernard
Jul 23, 2011·The British Journal of Dermatology·K YonedaY Kubota
Sep 3, 2013·International Journal of Cosmetic Science·R K BhogalG A Turner

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