PMID: 8962716Jan 1, 1996Paper

Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha

Growth Factors
J R GoldenringR J Coffey

Abstract

Overexpression of transforming growth factor-alpha (TGF-alpha) in the gastric mucosa of metallothionein-TGF alpha (MT-TGF alpha) transgenic mice leads to a marked alteration in the ontogeny of the fundic cellular lineages. Induction of the transgene leads to the over-production of mucous cells with a concomitant diminution in the development of parietal cell and chief cell lineages. We have sought to define more precisely the mucous cell lineages involved in the mucous cell hyperplasia in MT-TGF alpha mice by investigating the expression of trefoil peptides in MT-TGF alpha mice. MT-TGF alpha mice and their non-transgenic littermates were treated with cadmium sulfate beginning at 13 days of age. Animals were then sacrificed at intervals over the following 2 weeks and gastric mucosa was examined for expression of trefoil peptides and TGF alpha by immunohistochemistry and in situ hybridization. No TGF alpha mRNA expression could be demonstrated by in situ hybridization in non-transgenic mice. In MT-TGF alpha mice, in situ grains for TGF alpha mRNA were detected at the base of fundic glands in 13 day old animals, whereas the expression was observed more widely in the mucosa of older animals (28 days). TGF alpha immunoreactivity was...Continue Reading

References

Dec 1, 1992·The Journal of Clinical Investigation·M RomanoR J Coffey
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F HauserW Hoffmann

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Citations

Jun 2, 2000·Gastroenterology·J R GoldenringB D Car
Nov 3, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Melanie A GreeleyCharles G Plopper
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·D M Pritchard, S M C Przemeck
Aug 10, 2004·Gastroenterology·Sachiyo NomuraJames R Goldenring
May 9, 2007·Gastroenterology·Ki Taek NamJames R Goldenring
Jan 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sachiyo NomuraJames R Goldenring
Oct 16, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yukinori YamagataSachiyo Nomura
Nov 25, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masako OgawaJames R Goldenring
Apr 14, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·A S Giraud
Jun 5, 1998·The American Journal of Physiology·A P Majumdar, J R Goldenring

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