PMID: 7539715Jun 15, 1995Paper

Expression of tumor-associated polymorphic epithelial mucin and carcinoembryonic antigen in gastrointestinal carcinoid tumors. Implications for immunodiagnosis and immunotherapy

Cancer
T N Moyana, J Xiang

Abstract

Gastrointestinal neoplastic epithelium of glandular origin commonly produces N-linked and O-linked glycoproteins such as carcinoembryonic antigen (CEA) and tumor-associated polymorphic epithelial mucin (PEM). Antibodies to these glycoproteins increasingly are being used in immunodiagnosis and/or immunotherapy. Although GI carcinoid tumors have a neuroendocrine immunophenotype and generally have an indolent clinical course compared with their adenocarcinomatous counterparts, they also arise from undifferentiated crypt epithelium. The purpose of this study was to determine whether GI carcinoids similarly expressed epitopes for CEA and PEM. Thirty-nine GI carcinoid tumors from various topographic sites were analyzed by immunohistochemistry using the murine monoclonal antibodies B72.3, ACT19, and T84. The former two antibodies recognize epitopes in PEM, whereas the latter is an anti-CEA antibody, which was confirmed using enzyme-linked immunosorbent assays. The majority of carcinoid tumors (74%), particularly jejunoileal carcinoids, reacted for ACT19 antibody, whereas considerably fewer reacted for B72.3 (31%) and T84 (26%). The extent of staining was also greatest with ACT19. The GI mucosa adjacent to or overlying the carcinoid tu...Continue Reading

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Citations

Mar 1, 1997·Diseases of the Colon and Rectum·P C NearyD Bouchier-Hayes
Apr 16, 2005·Journal of Cellular Biochemistry·Ashakumary LakshmikuttyammaRajendra K Sharma
Aug 25, 1997·Experimental Cell Research·R V RajuR K Sharma
Jul 23, 1998·Critical Reviews in Biochemistry and Molecular Biology·P Van den SteenG Opdenakker
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ponniah SelvakumarRajendra K Sharma

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