PMID: 11920522Mar 29, 2002Paper

Expression of tumor rejection antigens in colorectal carcinomas

Cancer
Teruo SasatomiKazuo Shirouzu

Abstract

The authors recently reported that the SART2 and SART3 antigens encode tumor epitopes recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes (CTLs) established from esophageal carcinoma patients. The current study investigated these antigens to explore a potential molecule for specific immunotherapy for colorectal carcinoma patients. The SART2 and SART3 antigens were investigated by Western blotting in colorectal carcinoma cell lines and in cancer tissues. For induction of CTLs, peripheral blood mononuclear cells (PBMCs) of HLA A-24-positive cancer patients were stimulated in vitro with peptides. The 140 kD SART3 antigen was expressed in both the cytosol and nuclear fractions of all six colon carcinoma cell lines, 27 of 41 (65.9%) cytosol fractions, 30 of 41 (73.2%) nuclear fractions of colorectal carcinoma tissue samples, and in 0 of 7 non-tumorous tissues. The 100 kD SART2 antigen was expressed in the cytosol fractions of 2 of 6 colon carcinoma cell lines, 5 of 20 (25%) cytosol fractions of colorectal carcinoma tissue samples, and in 0 of 7 non tumorous tissues. HLA-A24-restricted CTLs cytotoxic to colon carcinoma cells were induced from PBMCs of colon carcinoma patients by stimulation with the two immuno...Continue Reading

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Citations

Aug 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Guangwei WeiEric J Huang
Sep 29, 2011·The Cancer Journal·Katherine KabakerHoward L Kaufman
Jul 5, 2013·BMC Molecular Biology·Khalid Amine TimaniJohnny J He
Dec 19, 2014·Expert Opinion on Investigational Drugs·Manik Amin, Albert Craig Lockhart
Feb 21, 2016·Life Sciences·Amanda WhitmillJohnny J He
Jul 9, 2004·Pathology, Research and Practice·Marc A ReymondHans Lippert
Jan 1, 2012·Vaccines·Aleksandra BartnikShi-Yu Yang
Jan 6, 2009·The Journal of Veterinary Medical Science·Yumi TakaishiHiromitsu Orima
Mar 1, 2006·The Journal of Biological Chemistry·Marco MaccaranaAnders Malmström

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