PMID: 3754961May 12, 1986Paper

Expression of two proopiomelanocortin genes in the pituitary gland of Xenopus laevis: complete structures of the two preprohormones

Nucleic Acids Research
G J Martens

Abstract

A number of cDNA clones corresponding to Xenopus POMC mRNA was isolated from a cDNA library constructed from Xenopus pituitary polyadenylated RNA. Characterization of the cDNA inserts revealed two groups of structurally different proopiomelanocortin mRNAs, indicating that two proopiomelanocortin genes are expressed to virtually the same level in Xenopus pituitary glands. From the mRNA structures the complete amino acid sequences of the two Xenopus preproopiomelanocortins could be deduced. Comparison with proopiomelanocortin mRNA and protein sequences from other species shows regions of high homology (including the portion of the prohormone located N-terminally of gamma-melanophore-stimulating hormone) and regions of extremely low homology (including the signal sequence).

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Citations

Mar 1, 1995·Endocrine·R A GelfandL Parker
Oct 1, 1991·Brain Research. Molecular Brain Research·M WongY P Loh
Nov 1, 1991·Molecular and Cellular Endocrinology·M C KeightleyP J Fuller
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N KitaharaG I Soma
Apr 8, 2003·General and Comparative Endocrinology·San-Tai ShenJohn Yuh-Lin Yu
May 24, 2003·Brain Research. Developmental Brain Research·Hélène TollemerHubert Vaudry
Dec 18, 2001·Brain Research. Molecular Brain Research·W H van den HurkG J Martens
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Jul 25, 1989·Nucleic Acids Research·F M Pan, W C Chang
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Feb 7, 2006·General and Comparative Endocrinology·Ryno NaudéHiroshi Kawauchi
Dec 17, 2005·General and Comparative Endocrinology·Hiroshi Kawauchi, Stacia A Sower
Dec 14, 1990·Biochemical and Biophysical Research Communications·E HilarioH Vaudry

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