Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women

The Journal of Clinical Endocrinology and Metabolism
A M CorbouldR J Rodgers

Abstract

Human adipose tissue is known to have 17 beta-oxidoreductase activity, interconverting estrone (E1) and estradiol (E2), as well as androstenedione (A) and testosterone (T). We examined both the subcutaneous abdominal and intra-abdominal (visceral) adipose tissue of women for expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) using ribonuclease (RNase) protection assay and RT-PCR/Southern blotting. Type 1 17 beta-HSD, which encodes the enzyme responsible for the conversion of E1 to E2 in the placenta and ovary, was expressed in the subcutaneous abdominal and intra-abdominal adipose tissue of women, but the messenger RNA transcripts were predominantly incompletely spliced and therefore unlikely to encode an active protein. A pseudogene for type 1 17 beta-HSD was also expressed in these tissues, but messenger RNA transcripts were again unspliced. Type 2 17 beta-HSD, which encodes an enzyme that can catalyze the conversion of T to A and E2 to E1, was expressed in both the subcutaneous abdominal and intra-abdominal adipose tissue of women. Type 3 17 beta-HSD was also expressed in adipose tissue from both sites studied. Type 3 17 beta-HSD encodes the enzyme that catalyzes the conversion of A to T in th...Continue Reading

Citations

Mar 1, 2012·Journal of Physiology and Biochemistry·Mirja RotinenIgnacio Encío
Oct 18, 2002·General and Comparative Endocrinology·Rebecca M MoorePaul M Rosenblum
Nov 7, 2006·The Journal of Steroid Biochemistry and Molecular Biology·R MindnichJ Adamski
Apr 5, 2014·General and Comparative Endocrinology·A Aceves-RamosM C Romano
Nov 6, 2008·American Journal of Physiology. Endocrinology and Metabolism·Karine BlouinAndré Tchernof
Mar 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P SipiläM Poutanen
Feb 4, 2005·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Apr 13, 1999·The Journal of Clinical Endocrinology and Metabolism·V L GreenS L Atkin
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Karine BlouinAndré Tchernof
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·David DiSilvestroOuliana Ziouzenkova
Oct 21, 2004·American Journal of Physiology. Endocrinology and Metabolism·Karine BlouinAndré Tchernof
Apr 9, 2020·European Journal of Applied Physiology·Paola Gonzalo-EncaboAlberto Pérez-López

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
S Andersson
The Journal of Steroid Biochemistry and Molecular Biology
S AnderssonL Wu
Journal of the Society for Gynecologic Investigation
K N Qin, R L Rosenfield
© 2021 Meta ULC. All rights reserved