PMID: 11932895Apr 5, 2002Paper

Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide galNAc N-acetylgalactosaminyl transferase-3 in relation to differentiation and prognosis in patients with colorectal carcinoma

Cancer
Kazunori ShibaoKimitoshi Kohno

Abstract

Tumor development usually is accompanied by alterations of O-glycosylation. Initial glycosylation of mucin-type, O-linked proteins is catalyzed by one of the UDP-GalNAc-polypeptide N-acetyl-galactosaminyl transferases, such as GalNAc-T3, which is expressed in adenocarcinoma cells. The authors investigated whether such expression influenced tumor differentiation or prognosis in patients with colorectal carcinoma. The expression of GalNAc-T3 was evaluated immunohistochemically in 106 paraffin embedded samples from surgically resected colorectal carcinomas and was related to patient and tumor characteristics. Western blot analysis was performed on seven samples of frozen tissue. Strong tumor expression of GalNAc-T3 predicted 5-year survival in patients with colorectal carcinoma (67.2% vs. 43.6% for weak expression; P = 0.017). GalNAc-T3 expression was not associated with age, gender, tumor size, tumor location, or disease stage but was related to histologic differentiation (P = 0.049) and depth of invasion (P = 0.031). Univariate analysis showed that strong GalNAc-T3 expression significantly enhanced the likelihood of survival. Multivariate Cox survival analysis identified enzyme expression as an independent prognostic factor that...Continue Reading

References

Aug 19, 1992·International Journal of Cancer. Journal International Du Cancer·B SchwartzY S Kim
May 1, 1990·Gastroenterology·C R Boland, G D Deshmukh
Mar 14, 1974·Biochimica Et Biophysica Acta·Y S Kim, J M Perdomo
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Jun 1, 1994·European Journal of Biochemistry·F VavasseurI Brockhausen
May 1, 1994·Gastroenterology·R S Bresalier
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·P D RyeM Bryne
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·K ShibaoH Itoh

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Citations

Jun 6, 2003·Biochimica Et Biophysica Acta·W KemmnerP M Schlag
Mar 16, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takahiro InoueMasazumi Tsuneyoshi
Dec 14, 2011·Hybridoma·Chunliang LiuShiliang Wu
May 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Yasuhiro MochizukiJun Amano
Apr 30, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Makoto IshikawaHirokazu Nagawa
Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joana GomesCelso A Reis
Mar 13, 2016·Biochimica Et Biophysica Acta·Joanne ChiaFrederic Bard
Mar 26, 2016·Frontiers in Oncology·Stefan MereiterCelso A Reis
Apr 17, 2007·Biochemical and Biophysical Research Communications·Chen WuDonggang Xu
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dahai ZhangYasuko Iwakiri
Jul 12, 2005·Bioorganic & Medicinal Chemistry·Howard C Hang, Carolyn R Bertozzi
Aug 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yoshikazu HaradaSohsuke Yamada
Nov 2, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Nora BeroisEduardo Osinaga
May 20, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Nuno T MarcosCelso A Reis
Nov 9, 2012·Clinical Chemistry·Nora BeroisEduardo Osinaga
Jul 29, 2006·Clinical Chemistry·Nora BeroisGilda Raguénez
May 29, 2018·Experimental and Therapeutic Medicine·Yanshao LiuJieyong Xing
Apr 1, 2010·Journal of Clinical Pathology·Celso A ReisLeonor David
Dec 4, 2016·Glycobiology·María Florencia FestariEduardo Osinaga
May 31, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masaru NodaKoji Kono
Mar 2, 2021·World Journal of Gastrointestinal Surgery·Yao Liu, Fang-Xing Peng

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