PMID: 7542297Jul 1, 1995Paper

Expression of V beta gene segments by Sezary cells

The Journal of Investigative Dermatology
G GorochovF Sigaux

Abstract

The T-cell receptor V beta repertoire expressed by Sezary cells was determined in a series of 16 patients whose samples have been shown to contain a majority of tumor cells. By using anti-V beta monoclonal antibodies, polymerase chain reaction analysis of expressed V beta, and, in selected cases, nucleotide sequencing, we have shown that the expressed V beta segments belong to five V beta families (V beta 5, V beta 6, V beta 8, V beta 13, and V beta 18), which contain a large fraction of the T-cell receptor V beta repertoire and do not share significant similarities in complementary determining region 4. V beta segments from these five families were also found to be strongly expressed by CD4 + CD7- peripheral blood cells obtained by fluorescence-activated cell sorting from two healthy donors. The diversity of the V beta repertoire expressed by Sezary cells appears to be similar to that expressed by circulating non-neoplastic T cells. These data do not support the hypothesis that a common superantigen is involved in the initiation of this form of cutaneous T-cell lymphoma.

Citations

Jun 1, 1995·The British Journal of Dermatology·F el SayedB Gorguet
Jan 19, 2006·Blood·Nicolas OrtonneArmand Bensussan
Nov 15, 2007·Cytogenetic and Genome Research·L KarenkoA Ranki
Apr 16, 1998·The British Journal of Dermatology·P Thor StratenJ Zeuthen
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elise A OlsenUNKNOWN Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer
Jan 18, 2006·Journal of Cutaneous Pathology·Eric C Vonderheid
Aug 21, 2013·Toxins·Andreas Willerslev-OlsenNiels Odum
Sep 1, 1996·The Journal of Investigative Dermatology·C M JackowM Duvic
Aug 19, 2007·The Journal of Investigative Dermatology·Nicolas OrtonneArmand Bensussan

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