PMID: 9531474Jun 11, 1998Paper

Expression of v-src in mammary epithelial cells induces transcription via STAT3

The Biochemical Journal
P D Smith, M R Crompton

Abstract

Transgenic mouse models of mammary tumorigenesis and analyses of human breast tumour samples have indicated a role for Src proteins in the tumorigenic process. The downstream effectors of Src function in mammary epithelial cells are less well understood. STAT proteins constitute a family of transcription factors whose activation by cytokine and non-cytokine receptors leads to tyrosine phosphorylation, dimerization and translocation from the cytoplasm to the nucleus. In the nucleus they activate the transcription of specific genes by binding to consensus DNA elements. STATs 1 and 3 can be activated by both cytokine and non-cytokine receptors, and bind as homodimers or heterodimers to viral simian sarcoma virus (sis)-inducible elements such as that found in the c-fos promoter. Here we report that one of the downstream effectors of Src function in mammary epithelial cells is STAT3. We demonstrate that v-src expression in mammary epithelial cells induces Tyr-705 phosphorylation, nuclear translocation and DNA binding of STAT3. Furthermore, we demonstrate that v-src can induce STAT3-dependent transcription. These observations are the first direct evidence that v-src can regulate transcription through the activation of STAT proteins, ...Continue Reading

Citations

Sep 23, 2003·Journal of Cellular Physiology·Valentina CalòAntonio Russo
Apr 25, 2007·Differentiation; Research in Biological Diversity·Liguo ChenJaspal Singh Khillan
Mar 15, 2015·Differentiation; Research in Biological Diversity·Young Rae JiZae Young Ryoo
Aug 31, 2000·Molecular Cell Biology Research Communications : MCBRC·R P de GrootL Koenderman
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M PerouD Botstein
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