PMID: 9647082Jul 1, 1998Paper

Expression of vascular adhesion molecules in saphenous vein coronary bypass grafts

The Annals of Thoracic Surgery
A H ChesterM H Yacoub

Abstract

Adhesion of blood elements to the endothelium is an important step in the development of vein graft disease. This study examines the expression of vascular adhesion molecules on explanted saphenous vein bypass grafts. Immunocytochemical staining was performed using explanted saphenous vein grafts from 28 patients. Antibodies against the endothelial markers CD31, von Willebrand factor, intercellular adhesion molecule-1, vascular adhesion molecule-1, and E-selectin were used. Staining for CD31 and von Willebrand factor demonstrated the presence of endothelial cells in the lumen and the vasa vasorum. Expression of intercellular adhesion molecule-1 was variable between grafts, whereas vascular adhesion molecule-1 and E-selectin were almost always absent on the luminal endothelium. In contrast, the endothelium of the vasa vasorum stained positively for intercellular adhesion molecule-1 and vascular adhesion molecule-1, and was also seen on nonendothelial cells within the vessel wall. Expression of these adhesion molecules did not vary with the severity of vein graft disease. This study highlights the blood vessels in the adventitia as possible sites for the adhesion and migration of cells into the vessel wall.

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Citations

Mar 28, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ayae TakaseYuichiro Ogura
Aug 10, 2000·Journal of the American College of Cardiology·J A de LemosP M Ridker
Jun 17, 2014·Canadian Journal of Physiology and Pharmacology·Swastika SurDevendra K Agrawal
Mar 21, 2007·Journal of Cellular and Molecular Medicine·Tobias WalkerGerhard Ziemer
Mar 28, 2006·The Annals of Thoracic Surgery·Axel SchlittMichael Buerke
Jul 17, 2010·Pathology·Sayyed Mohammad Hossein GhaderianReza Akbarzadeh Najar
Jun 12, 2004·Journal of Vascular Surgery·Thomas A AbbruzzeseMichael S Conte
Oct 7, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G L Sayer, P D C Smith
Jun 1, 2010·Vascular Medicine·Mital DesaiAlexander M Seifalian
Feb 1, 2007·Journal of Vascular Research·David KachlikMarek Setina
Mar 20, 2003·Journal of Cardiac Surgery·Stephen J White, Andrew C Newby
Apr 24, 2020·VASA. Zeitschrift für Gefässkrankheiten·Kostas TepelenisPanagiotis Kitsoulis

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