PMID: 11336877May 5, 2001Paper

Expression of vascular endothelial growth factor in third-trimester placentas is not increased in growth-restricted fetuses

Journal of the Society for Gynecologic Investigation
J Y TseA N Cheung

Abstract

Vascular endothelial growth factor (VEGF) is considered the growth factor that stimulates vasculogenesis and angiogenesis. Recent studies have demonstrated its role in regulating placental growth and invasion. Its expression can be upregulated by hypoxia. Intrauterine growth restriction (IUGR) is thought to be associated with inadequate placental perfusion, which might result from a failure in the development of the villous vascular network. Our present study was undertaken to examine the relationship between VEGF expression and IUGR in pregnancies with preserved umbilical artery end-diastolic flow. VEGF Expression was determined by immunohistochemical analysis of placentas from 17 pregnancies with normal infant birth weight and 17 pregnancies complicated by IUGR. We found no significant differences in the expression of VEGF in villous syncytiotrophoblasts and intermediate trophoblasts in maternal decidua between IUGR and normal pregnancies. However, in both groups there was a strong correlation in the expression of VEGF with villous syncytiotrophoblasts and intermediate trophoblasts. In normal and IUGR pregnancies the infants' Apgar scores at birth were significantly correlated with VEGF staining in both syncytiotrophoblasts a...Continue Reading

Citations

Feb 19, 2008·The Journal of Infectious Diseases·Philippe BoeufStephen J Rogerson
Apr 4, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·M EgborP D Sibbons
Jun 22, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Tooba ShoaibRosa M Espinosa-Marzal
Feb 8, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M ShaarawyI Abdel-Mohsen
May 9, 2003·Pediatric Research·Doron KreiserPhyllis A Dennery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.