Expression of vascular endothelial growth factor receptor-3 mRNA in the rat developing forebrain and retina

The Journal of Comparative Neurology
Jeong-Sun ChoiMun-Yong Lee

Abstract

Vascular endothelial growth factor receptor (VEGFR)-3, a receptor for VEGF-C and VEGF-D, is expressed in neural progenitor cells, but there has been no comprehensive study of its distribution in the developing brain. Here, the temporal and cell-specific expression of VEGFR-3 mRNA was studied in the developing rat forebrain and eye. Expression appeared along the ventricular and subventricular zones of the lateral and third ventricles showing ongoing neurogenesis as early as embryonic day 13 but was progressively down-regulated during development and remained in the subventricular zone and rostral migratory stream of the adult forebrain. VEGFR-3 expression was also detectable in some differentiating and postmitotic neurons in the developing cerebral cortex, including Cajal-Retzius cells, cortical plate neurons, and subplate neurons. Expression in the subplate increased significantly during the early postnatal period but was absent by postnatal day 14. It was also highly expressed in nonneural tissues of the eye during development, including the retinal pigment epithelium, the retinal ciliary margin, and the lens, but persisted in a subset of cells in the pigmented ciliary epithelium of the adult eye. In contrast, there was weak o...Continue Reading

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Citations

Nov 13, 2010·Cellular and Molecular Neurobiology·Yun HouMun-Yong Lee
Jan 29, 2011·Molecular Neurobiology·Sreenivasan Ponnambalam, Mario Alberghina
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Jan 16, 2021·Proceedings of the National Academy of Sciences of the United States of America·Éva MezeyMiklós Palkovits
Feb 15, 2020·Molecular Therapy. Methods & Clinical Development·Annabelle SchlüterDaniela Mauceri

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