Expression of vascular endothelial growth factor in oral squamous cell carcinoma

Journal of the Korean Association of Oral and Maxillofacial Surgeons
Seok-Kon KimKyung-Wook Kim

Abstract

The goal of this study was to determine the correlation of clinicopathological factors and the up-regulation of vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma. Immunohistochemical staining of VEGF and quantitative real-time polymerase chain reaction (RT-PCR) of VEGF mRNA were performed in 20 specimens from 20 patients with oral squamous cell carcinoma and another 20 specimens from 20 patients with carcinoma in situ as a controlled group. The results were as follows: 1) In immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, high-level staining of VEGF was observed. Significant correlation was observed between immunohistochemical VEGF expression and histologic differentiation, tumor size of specimens (Pearson correlation analysis, significance r>0.6, P<0.05). 2) In VEGF quantitative RT-PCR analysis, progressive cancer showed more VEGF expression than carcinoma in situ. Paired-samples analysis determined the difference of VEGF mRNA expression level between cancer tissue and carcinoma in situ tissue, between T1 and T2-4 (Student's t-test, P<0.05). These findings suggest that up-regulation of VEGF may play a role in the angiogenesis and progression of or...Continue Reading

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Citations

Nov 28, 2017·Omics : a Journal of Integrative Biology·Wendy D'Souza, Dhananjaya Saranath
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Thanun SritipphoAnak Iamaroon
Jul 19, 2018·Oncotarget·Cameron GoertzenMarco Magalhaes
Sep 1, 2020·Cancer Biomarkers : Section a of Disease Markers·Akhilesh KrishnaAbbas Ali Mahdi

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