PMID: 9550144Apr 29, 1998Paper

Expression of VGF mRNA in the adult rat central nervous system

The Journal of Comparative Neurology
S E Snyder, Stephen R J Salton

Abstract

VGF is a secretory peptide precursor that is expressed and processed by neuronal cells in a cell type-specific fashion. In addition, VGF transcription and secretion are rapidly and relatively selectively induced by neurotrophins and depolarization in vitro. To gain insight into the possible function(s) of VGF in the nervous system, we have carried out a detailed examination of the distribution of VGF mRNA in the adult rat central nervous system by using in situ hybridization. Robust expression was detected in many neurons throughout the brain and spinal cord, in several types of neurons in the retina, and in presumptive chromaffin cells of the adrenal medulla. In the brain, prominent expression of VGF mRNA was observed in neurons of the main and accessory olfactory bulbs; in the anterior olfactory nucleus; in the induseum griseum and taenia tecta; in the olfactory tubercle; in CA1-CA3, the hilus of the dentate gyrus, and the subicular complex of the hippocampal formation; in the piriform, periamygdaloid, transitional, and lateral entorhinal cortices; in the endopiriform nucleus; in the hypothalamus, particularly the preoptic, periventricular, supraoptic, suprachiasmatic, and arcuate nuclei; and in a number of septal, thalamic, ...Continue Reading

Citations

Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ozlem BozdagiStephen R J Salton
Nov 28, 2000·Annual Review of Genetics·S W RobinsonR D Cone
Nov 22, 2017·Molecular Psychiatry·C JiangS R Salton

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