Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6

PloS One
Wanxue WangYihua Yang

Abstract

The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown. This study explored abnormal expression of Yin Yang 1 (YY1) in cervical cancer and its correlation with the expression of E-cadherin and human papillomavirus (HPV) 16 E6. YY1, E-cadherin and HPV16 E6 expression were detected by immunohistochemistry in 90 cervical tissue specimens collected from 30 patients with hysteromyoma, 15 patients with CIN I, 15 patients with CIN II-III, and 30 patients with CSCC. The H-score method was employed to measure the expression of YY1, E-cadherin and HPV16 E6. Increased expression of YY1 and HPV16 E6, and the decreased expression levels of E-cadherin were strongly associated with malignant transformation of the cervical epithelium and the histological progression of CSCC. The expression of YY1 in cervical tissues was inversely correlated with E-cadherin expression, and positively correlated with HPV16 E6 expression. Expression of YY1 in CSCC tissues was not significantly correlated with tumor differentiation, but was significantly correlated with an advanced clinical stage of CSCC. These results sugges...Continue Reading

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Citations

Dec 12, 2019·Frontiers in Oncology·Sailu SarvagallaSivakumar Vallabhapurapu
Mar 24, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Ewa JablonskaTong Wang

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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