Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts

Gene Expression Patterns : GEP
Silke PittlikGerrit Begemann

Abstract

The vitamin A-derived morphogen retinoic acid (RA) plays important roles during the development of chordate animals. The Aldh1a-family of RA-synthesizing enzymes consists of three members, Aldh1a1-3 (Raldh1-3), that are dynamically expressed throughout development. We have searched the known teleost genomes for the presence of Raldh family members and have found that teleost fish possess orthologs of Aldh1a2 and Aldh1a3 only. Here we describe the expression of aldh1a3 in the zebrafish, Danio rerio. Whole mount in situ hybridization shows that aldh1a3 is expressed during eye development in the retina flanking the optic stalks and later is expressed ventrally, opposite the expression domain of aldh1a2. During inner ear morphogenesis, aldh1a3 is expressed in developing sensory epithelia of the cristae and utricular macula and is specifically up-regulated in epithelial projections throughout the formation of the walls of the semicircular canals and endolymphatic duct. In contrast to the mouse inner ear, which expresses all three Raldhs, we find that only aldh1a3 is expressed in the zebrafish otocyst, while aldh1a2 is present in the periotic mesenchyme. During larval stages, additional expression domains of aldh1a3 appear in the ant...Continue Reading

References

Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Aug 29, 2001·Bioinformatics·J P Huelsenbeck, F Ronquist
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Begemann, A Meyer
Mar 29, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tanya T WhitfieldBryan Phillips
Feb 27, 2003·Chemico-biological Interactions·Nickolas A Sophos, Vasilis Vasiliou
Feb 28, 2003·Developmental Biology·Wiebke HerzogMatthias Hammerschmidt
Oct 8, 2003·Systematic Biology·Stéphane Guindon, Olivier Gascuel
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Valérie DupéNorbert B Ghyselinck
Nov 30, 2004·Gene Expression Patterns : GEP·Arnaud Marlier, Thierry Gilbert
Jan 14, 2005·Bioinformatics·Federico AbascalDavid Posada
Apr 15, 2006·The Journal of Comparative Neurology·Raymond RomandEri Hashino
Aug 24, 2006·Evolution & Development·Cristian CañestroRicard Albalat
Dec 7, 2006·Nucleic Acids Research·T J P HubbardE Birney

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Citations

May 7, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yann GibertVincent Laudet
Jun 16, 2011·Development, Growth & Differentiation·Susumu UjiTohru Suzuki
Jan 29, 2011·BMC Developmental Biology·Yann GibertVincent Laudet
Jun 30, 2011·Human Genomics·Brian JacksonVasilis Vasiliou
Jan 10, 2009·Disease Models & Mechanisms·Kirsten DuttonTanya T Whitfield
Sep 17, 2013·PloS One·Adriana Rodríguez-MaríJohn H Postlethwait
Apr 13, 2013·The International Journal of Biochemistry & Cell Biology·Ricardo Lara-RamírezMichael Schubert
Mar 5, 2009·The Journal of Comparative Neurology·Luis Oscar Sánchez-GuardadoMatías Hidalgo-Sánchez
May 25, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amrita MandalJoshua S Waxman
May 18, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Silke Pittlik, Gerrit Begemann
Jun 15, 2014·Biochimica Et Biophysica Acta·Eric SamarutYann Gibert
Apr 26, 2011·Biochimica Et Biophysica Acta·Sandeep KumarGregg Duester
Sep 21, 2010·Biochimica Et Biophysica Acta·Patricia A GongalAndrew J Waskiewicz
Sep 18, 2012·Developmental Biology·Maija K GarnaasWolfram Goessling
Oct 6, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yehuda Shabtai, Abraham Fainsod
Apr 26, 2017·Journal of Molecular Endocrinology·Marcel J M Schaaf
Jan 8, 2019·Genesis : the Journal of Genetics and Development·Berardino PetrelliAbraham Fainsod
Jun 4, 2019·Genesis : the Journal of Genetics and Development·Antionette L Williams, Brenda L Bohnsack
Dec 30, 2011·American Journal of Physiology. Endocrinology and Metabolism·Liraz LeviEsther Lubzens
Aug 11, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sheila Cardeña-NúñezMatías Hidalgo-Sánchez
Mar 24, 2012·Cell & Bioscience·Richard Kin Ting KamHui Zhao

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