Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist

Behavioural Brain Research
Shinsuke SatohHiroshi Yoneda

Abstract

The present study examined the expression pattern of FOS in the hypothalamic peptide neurons during the sleep-dominant state induced by an adenosine A2A receptor agonist. The control rats, those that received the microdialysis-perfusion of their ventral striatum with artificial cerebrospinal fluid in the dark-active phase, spent 24% of the 90-min period prior to sacrifice in non-rapid eye movement (non-REM) sleep and 2.3% of that in REM sleep. These rats exhibited FOS, a transcription factor, in 21% of their orexin neurons and in 1.0% of their melanin-concentrating hormone (MCH) neurons in the perifornical/lateral hypothalamic areas. However, the rats perfused with 50 microM CGS21680, an adenosine A2A receptor agonist, spent 60% of the 90-min period prior to sacrifice in non-REM sleep and 11% of that in REM sleep. These rats exhibited FOS in 1.7% of their orexin neurons and FOS in 0.5% of their MCH neurons. When the sleep-dominant state was disturbed by mild stimulation and the rats were kept in the sleepy state by treatment with a sleep-inducing dose of CGS21680, the rats exhibited FOS in 13.3% of their orexin neurons, which percentage was about half of that for the control rats. These results suggest that the sleep-promoting ...Continue Reading

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Citations

Sep 13, 2011·Progress in Neurobiology·Geoffrey BurnstockPeter Illes
Jun 3, 2010·Biomedical and Environmental Sciences : BES·Gen-Xiang MaoZhen Wang
Aug 8, 2009·Peptides·Christelle PeyronPatrice Fort
May 1, 2012·The European Journal of Neuroscience·Mark R ZielinskiJames M Krueger
Jul 19, 2018·The Journal of Comparative Neurology·Manasi IyerMatthew E Carter
May 31, 2008·Nature Reviews. Drug Discovery·Keith A Wafford, Bjarke Ebert
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Jul 17, 2012·Anesthesia and Analgesia·Li-Na ZhangHai-Long Dong
Apr 25, 2017·Neuroscience Research·Yo Oishi, Michael Lazarus

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