PMID: 7524627Jul 1, 1994Paper

Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes

Mechanisms of Development
M KarperienL H Defize

Abstract

In this paper we describe the cloning of the mouse Parathyroid Hormone/Parathyroid Hormone related Peptide Receptor (PTH/PTHrPR) cDNA and expression of its mRNA during mouse postimplantation development from day 5.5 until day 15.5 post coitum (p.c.). In support of a model from previous studies, in which parietal endoderm differentiation is regulated by the interaction of the PTH/PTHrPR and Parathyroid Hormone related Peptide (PTHrP), high levels of PTH/PTHrPR mRNA levels were detected in developing parietal endoderm from day 5.5 p.c. and onwards. In the embryo proper, PTH/PTHrPR mRNA expression was mainly detected at sites of epithelium/mesenchyme interactions, starting at day 9.5 p.c. in the epithelium of the intestine and later in the mesenchyme of the lung, the epithelium of meso- and metanephric tubuli, the dermis and at all sites where bone formation takes place. The complexity of the PTH/PTHrPR expression pattern suggests tight developmental regulation and indicates multiple roles in embryogenesis for the receptor and its ligands, not only in extraembryonic tissue but also in the formation of various organs.

References

Jul 15, 1992·Biochemical and Biophysical Research Communications·L X ZhouA W Norman
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S WernerL T Williams
May 1, 1992·Journal of Cellular Biochemistry·A W Norman
Jun 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·C L MummeryS Shen
Dec 1, 1990·Journal of Molecular Endocrinology·C MonizA M McGregor
Jan 1, 1986·Differentiation; Research in Biological Diversity·L B Grabel, J E Casanova
Jan 1, 1984·Differentiation; Research in Biological Diversity·B L Hogan, R Newman
Nov 1, 1981·The American Journal of Anatomy·A A Ten Have-Opbroek
Aug 1, 1982·The Journal of Cell Biology·E M Jones-VilleneuveV I Kalnins
Jan 1, 1993·The Journal of Cell Biology·A van de StolpeL H Defize
Feb 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Siobán D HarlowUNKNOWN STRAW + 10 Collaborative Group

❮ Previous
Next ❯

Citations

Jun 25, 2013·Differentiation; Research in Biological Diversity·Simone ProbstAimée Zuniga
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·C S KovacsH M Kronenberg
Jun 23, 2004·American Journal of Respiratory Cell and Molecular Biology·John S Torday, Virender K Rehan
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A HollnagelG Gross
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B C van der EerdenJ M Wit
Jul 14, 2012·PPAR Research·Virender K Rehan, John S Torday
Jan 18, 2005·Mechanisms of Development·Manvendra K SinghAndreas Kispert
Jun 14, 2005·Current Topics in Developmental Biology·Joanna PriceSteve Allen
Jul 25, 2006·International Review of Cytology·Julie Lafond, Lucie Simoneau
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lewis P RubinHenry M Kronenberg
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·C KappenR Finnell
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Esmond J Sanders, Steve Harvey
Feb 28, 2002·Endocrinology·Robin VargheseGabriel E Dimattia
Nov 7, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S Torday, V K Rehan
Dec 13, 2003·Endocrine Reviews·B C J van der EerdenJ M Wit
May 16, 2019·British Journal of Pharmacology·T John Martin, Rachelle W Johnson
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S Torday, V K Rehan
Apr 5, 2017·Frontiers in Pediatrics·John S Torday, Heber C Nielsen
Sep 28, 1998·The American Journal of the Medical Sciences·J S TordayL P Rubin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.