Abstract
The Popdc2 gene is a member of the Popeye domain containing gene family encoding membrane proteins with prominent expression in striated and smooth muscle tissue. After introducing a LacZ reporter gene into the Popdc2 locus, expression was studied during embryonic development and postnatal life. At embryonic day (E) 7.5, expression was present in cardiac and extraembryonic mesoderm. At E10.5, expression was found in heart, somites, and mesothelial cells lining the coelom. At E12.5, expression was present in the coelomic mesothelium, pericardial and myocardial layer of the heart, skeletal muscle, bladder, gut, and umbilical vessels. Postnatal expression was found in cardiac and skeletal muscle and in the smooth muscle layer of colon, rectum, and bladder. In the stomach, Popdc2 was exclusively present in the pyloric epithelium. In conclusion, Popdc2 is expressed in various muscle and nonmuscle cell types during embryonic development and in postnatal life.
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Citations
Feb 23, 2012·The Journal of Clinical Investigation·Alexander FroeseThomas Brand
May 21, 2014·Journal of Cardiovascular Development and Disease·Thomas BrandRoland F R Schindler
Apr 9, 2013·Trends in Cardiovascular Medicine·Subreena SimrickThomas Brand
Mar 22, 2014·Biochemical Society Transactions·Thomas BrandRoland F R Schindler
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Mar 14, 2018·Journal of Cardiovascular Development and Disease·Thomas Brand
Feb 11, 2009·Folia Parasitologica·Frantisek MoravecFabio Macchioni
Sep 26, 2019·Biochemical Society Transactions·Thomas Brand
Dec 11, 2019·Cells·Johanna Ndamwena AmunjelaThomas Brand
Jun 15, 2019·Journal of Muscle Research and Cell Motility·Alexander H SwanThomas Brand
Jun 28, 2016·Journal of Cardiovascular Development and Disease·Roland Fr SchindlerThomas Brand
Jun 15, 2016·Journal of Cardiovascular Development and Disease·Roland F R SchindlerThomas Brand