Expression pattern of RAGE and IGF-1 in the human fetal ovary and ovarian serous carcinoma

Acta histochemica
Ana PoljicaninKatarina Vukojevic

Abstract

The expression pattern of RAGE and IGF-1 proteins in different ovarian cell lineages was histologically analyzed in six fetal, nine adult human ovaries, and nine serous ovarian carcinomas (OSC) using immunohistochemical methods. Mild expression of IGF-1 in ovarian surface epithelium (Ose) and oocytes in the 15-week human ovaries increased to moderate or strong in the stromal cells, oocytes and follicular cells in week 22. Occasional mild RAGE expression was observed in Ose during week 15, while strong expression characterized primordial follicles in week 22. In the reproductive human ovary, IGF-1 was mildly to moderately expressed in all ovarian cell lineages except in theca cells of the tertiary follicle where IGF-1 was negative. RAGE was strongly positive in the granulosa cells and some theca cells of the tertiary follicle, while negative to mildly positive in all cells of the secondary follicle. In the postmenopausal human ovary IGF-1 and RAGE were mildly expressed in Ose and stroma. In OSC, cells were strongly positive to IGF-1 and RAGE, except for some negative stromal cells. Different levels of IGF-1 and RAGE co-expression characterized fetal ovarian cells during development. In reproductive ovaries, IGF-1 and RAGE were c...Continue Reading

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Citations

Apr 22, 2015·Acta histochemica·Gaetano MagroRosalba Parenti
Nov 5, 2016·Cancer Biomarkers : Section a of Disease Markers·Farzaneh RahimiMaryam Nankali
Jul 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Linn Salto MamsenClaus Yding Andersen

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