Expression pattern of REIC/Dkk-3 in mouse squamous epithelia

Clinical and Experimental Dermatology
Ken KataokaNam-Ho Huh

Abstract

The REIC/Dkk (reduced expression in immortalized cells/Dickkopf-3) gene was originally identified as a tumour-suppressor gene with reduced expression in immortalized cells, cancer-cell lines and tumour tissues. Of the four members of the Dkk family, the REIC/Dkk-3 protein is unique in terms of DNA sequence, expression profiles and biological functions. In this study, we investigated and compared the expression patterns of the REIC/Dkk-3 protein in mouse squamous epithelia. Expression of REIC/Dkk-3 in the back skin was localized to the upper layer of the interfollicular epidermis, and the inner root sheath of hair follicles. Expression of REIC/Dkk-3 was detected in the ear skin, oral mucosa, tongue, oesophagus, uterine cervix, footpad and tail skin, but not in the cornea. Interestingly, expression was localized to the upper layers of these epithelial tissues. The physiological function of REIC/Dkk-3 is still unclear, but our detailed observation highlight its unique expression pattern in squamous epithelia.

References

Feb 1, 2000·Biochemical and Biophysical Research Communications·T TsujiM Namba
Nov 16, 2001·Biochemical and Biophysical Research Communications·T TsujiM Namba
Jan 6, 2006·The Journal of Clinical Investigation·Manabu OhyamaJonathan C Vogel
Mar 13, 2009·The Journal of Biological Chemistry·Masakiyo SakaguchiNam-ho Huh
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Makoto KisoYumiko Saga
Sep 3, 2010·Oncology Reports·G PannoneL Lo Muzio
Feb 18, 2011·Experimental Dermatology·Gang DuNam-Ho Huh

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