Expression patterns and prognostic values of Nrf2 and Keap1 in nasopharyngeal carcinoma

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
X K Ma, J S Liu

Abstract

Objective:To investigate the expression of Nrf2 and Keap1 in nasopharyngeal carcinoma (NPC) and to analyze the relationship between the expression of Nrf2 and Keap1 and the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma. Method:A total of 108 patients with biopsy-proven nonkeratinizing squamous cell carcinoma-undifferentiated type with available biopsy specimens for tissue microarray (TMA) construction were selected. The relationship between Nrf2 and Keap1 protein expression and the prognosis of radiotherapy in patients with nasopharyngeal carcinoma was analyzed. Result: The overall 5-year disease free survival (DFS) and overall survival(OS) rates were 57.4% and 70.2%, respectively. The 5-year DFS rate was 59.4% in the low nuclear Nrf2 expression group, and 53.8% in the high nuclear Nrf2 expression group. The 5-year DFS rate was 42.2% in the low cytoplasmic Keap1 expression group, and 68.2% in the high cytoplasmic Keap1 expression group. The 5-year OS rate was 70.8% in the low nuclear Nrf2 expression group, and 69.2% in the high nuclear Nrf2 expression group. The 5-year OS rate was 55.6% in the low cytoplasmic Keap1 expression group, and 80.9% in the high cytoplasmic Keap1 expression group....Continue Reading

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