Expression patterns of antioxidant genes in human SH-SY5Y cells after treatment with methadone

Psychiatry Research
Khyber Saify, Mostafa Saadat

Abstract

The expression levels of nine antioxidant genes in SH-SY5Y cells exposed to methadone (final concentrations 1-20µM) were investigated. Based on this study the genes could be categorized on three different groups. The number of down-regulated genes were increased as a function of exposure time (P=0.004). The methadone associated mRNA alterations were modulated by N-acetyl-cysteine. These findings suggested that different pathways for regulation of antioxidant genes could be active after exposing of SH-SY5Y cells to methadone; and also suggested that methadone might act by inducing the reactive oxygen species.

References

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Citations

May 27, 2016·Environmental Health and Preventive Medicine·Khyber SaifyMostafa Saadat
Jul 29, 2017·Nordic Journal of Psychiatry·Nazanin Kordestanian, Mostafa Saadat
Feb 16, 2018·DNA and Cell Biology·Hamideh Mahmoudinasab, Mostafa Saadat
Nov 23, 2017·Environmental Health and Preventive Medicine·Khyber Saify, Mostafa Saadat
Aug 20, 2018·Biochemical Genetics·Majede Rezaei, Mostafa Saadat
Dec 29, 2016·Open Access Macedonian Journal of Medical Sciences·Hamideh Mahmoudinasab, Mostafa Saadat

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