PMID: 11342977May 9, 2001Paper

Expression patterns of cancer testis antigens in testicular germ cell tumors and adjacent testicular tissue

The Journal of Urology
T YuasaY Okada

Abstract

The human cancer-testis antigens (CTAs) are a group of tumor specific antigens recognized by cytotoxic T lymphocytes whose expression occurs in human malignancies as well as in normal testicular tissue. We studied a series of CTA gene transcripts in testicular germ cell tumors of various histological types to test the hypothesis that the expression of CTA in testicular germ cell tumors reflects developmental stages of tumorigenesis rather than constitutive tumor antigens recognized by cytotoxic T lymphocytes. Total RNA was obtained from 31 primary and 3 metastatic testicular germ cell tumors, and 11 parenchymal tissues adjacent to the testicular germ cell tumors. We performed an expression study of the CTA genes MAGE-A, MAGE-B, GAGE, PAGE-1, HOM-MEL-40 (SSX2), NY-ESO-1, LAGE-1 and SCP-1 in these samples using reverse transcriptase-polymerase chain reaction. The results showed that expression patterns of CTA genes depended on the histological differentiation of the testicular germ cell tumors. Overall CTA expression was more common in seminomas than in nonseminomatous germ cell tumors. Specifically all 13 seminomas (100%) demonstrated the positive expression of MAGE-B1 and MAGE-B2, while 3 of 17 nonseminomatous germ cell tumor s...Continue Reading

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Citations

Aug 12, 2005·Cell and Tissue Research·Catherine M BrowneKate L Loveland
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J W OosterhuisL H J Looijenga
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Nov 29, 2007·International Journal of Cancer. Journal International Du Cancer·Jean-Philippe TheurillatHolger Moch
May 15, 2013·Endocrine Reviews·John M HutsonNan Chen

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