Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis

Leukemia & Lymphoma
Lei FanJian-Yong Li

Abstract

Different combinations of biomarkers analyzed by flow cytometry are critical for the accurate diagnosis of leukemic B-cell chronic lymphoproliferative disorders (B-CLPDs). We investigated CD200 and CD148 expression patterns of blood or bone marrow from 374 cases of B-CLPD by multicolor flow cytometry. Our results showed that CD200 and CD148 expression patterns distinguished different types of B-CLPD. CD200 mean fluorescence intensity (MFI) or CD148 MFI had a high sensitivity and specificity to differentiate mantle cell lymphoma (MCL) from chronic lymphocytic leukemia (CLL). Furthermore, CD148 MFI/CD200 MFI ratio > 4.79 produced a specificity of 94.46% (95% confidence interval [CI]: 91.04-96.87%) and a sensitivity of 100% (95% CI: 88.78-100.0%) in establishing the diagnosis of MCL in differential diagnosis between MCL and CLL. We therefore conclude that the combination of CD200 and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL.

References

Jan 1, 1987·Immunogenetics·G W McCaughanA N Barclay
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A OstmanN K Tonks
Apr 11, 2003·Leukemia & Lymphoma·Henry Y DongDavid M Dorfman
Aug 31, 2006·British Journal of Haematology·Larissa BelovRichard I Christopherson
Oct 31, 2006·Leukemia & Lymphoma·Clive S Zent
Jan 11, 2007·American Journal of Clinical Pathology·Adam C SeegmillerNitin J Karandikar
Jan 26, 2007·Leukemia·A TonksR L Darley
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anke Kretz-RommelKatherine S Bowdish
Dec 18, 2007·Expert Opinion on Biological Therapy·Anke Kretz-Rommel, Katherine S Bowdish
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anke Kretz-RommelKatherine S Bowdish
Jan 17, 2008·Blood·Fiona E Craig, Kenneth A Foon
Mar 12, 2008·European Journal of Haematology·M DungarwallaC E Dearden
Oct 21, 2010·American Journal of Clinical Pathology·David M Dorfman, Aliakbar Shahsafaei
Dec 1, 2010·Methods in Molecular Biology·Katherine R CalvoMaryalice Stetler-Stevenson
Feb 1, 2011·British Journal of Haematology·Horatiu OlteanuSteven H Kroft
Nov 9, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Nermeen Ahmed El DesoukeyRasha Faragaly Mohammed
Dec 20, 2011·American Journal of Clinical Pathology·Daisy AlapatRobert B Lorsbach
Nov 19, 2013·Cytometry. Part B, Clinical Cytometry·Alex F SandesEdgar G Rizzatti

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Citations

Dec 29, 2017·Journal of Clinical Laboratory Analysis·Marc SorigueJordi Junca
Oct 18, 2018·Cytometry. Part B, Clinical Cytometry·Alba MoraJosep Nomdedeu
Jan 10, 2018·Cytometry. Part B, Clinical Cytometry·Marc SorigueJordi Junca
Nov 7, 2019·Cytometry. Part B, Clinical Cytometry·Marc SorigueCristian Morales-Indiano
Jul 28, 2020·Cytometry. Part B, Clinical Cytometry·Joerg HoffmannCornelia Brendel
Nov 6, 2020·Journal of Clinical and Experimental Hematopathology : JCEH·Takayoshi UchiyamaSadao Aoki
Dec 17, 2020·Frontiers in Oncology·Giovanni D'ArenaLuca Laurenti
Jul 17, 2021·Current Oncology Reports·Krista M IsaacMichael E Williams

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