Expression patterns of cytokine, growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis

World Journal of Gastroenterology : WJG
Shu YangTheresa May Chin Tan

Abstract

To examine the differences in the responses of normal and cirrhotic livers to partial hepatectomy in relation to the factors influencing liver regeneration. Cirrhosis was induced in rats by administration of thioacetamide. Untreated rats were used as controls. The control rats as well as the cirrhotic rats were subjected to 70% partial hepatectomy. At different time points after hepatectomy, the livers were collected and the levels of cytokines, growth factors and cell cycle proteins were analyzed. After hepatectomy, the cirrhotic remnant expressed significantly lower levels of cyclin D1, its kinase partner, cdk4, and cyclin E as compared to the controls up to 72 h post hepatectomy. Significantly lower levels of cyclin A and cdk2 were also observed while the cdk inhibitor, p27 was significantly higher. In addition, the cirrhotic group had lower IL-6 levels than the control group at all time points up to 72 h following resection. The data from our study shows that impaired liver regeneration in cirrhotic remnants is associated with low expression of cyclins and cdks. This might be the consequence of the low IL-6 levels in cirrhotic liver remnant which would in turn influence the actions of transcription factors that regulate gen...Continue Reading

References

Oct 1, 1992·The American Journal of Physiology·P AkermanA M Diehl
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T Morimoto, W Isselhard
Jan 1, 1992·Scandinavian Journal of Gastroenterology·U BrooméK G Sundqvist
Jan 1, 1991·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T KurokawaH Takagi
May 1, 1995·Molecular and Cellular Biology·M OhtsuboM Pagano
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M NakanishiJ R Smith
Nov 18, 1994·Cell·C J Sherr
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N FaustoE M Webber
Jan 1, 1995·Journal of Gastroenterology and Hepatology·K F Decker, M Y Obolenskaya
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H AlbrechtM Y Hu
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Apr 1, 1997·Genes & Development·J LaBaerE Harlow
Nov 25, 1997·Surgery·J A EhrenfriedB M Evers
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YamadaN Fausto
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M JaumotO Bachs
Dec 22, 1999·The American Journal of Physiology·J H AlbrechtC L Ahonen
Mar 23, 2000·Journal of Hepatology·N Fausto
Jul 18, 2000·Gut·K L StreetzC Trautwein
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yukiko InoueKenji Fujiwara
Jun 20, 2003·Cell Proliferation·Katrien VermeulenZwi N Berneman
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alex BlindenbacherMarkus H Heim
Jan 28, 2004·Cell·Andrew W Murray
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Malgorzata BorowiakCarmen Birchmeier
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Rebecca Taub

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Citations

Jan 17, 2012·International Journal of Experimental Pathology·Edina BugyikPeter Nagy

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