Expression patterns of FGF receptors in the developing mammalian cochlea.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Toshinori HayashiOlivia Bermingham-McDonogh

Abstract

Many studies have shown the importance of the fibroblast growth factor (FGF) family of factors in the development of the mammalian cochlea. There are four fibroblast growth factor receptors (FGFR1-4) and all four are expressed in the cochlea during development. While there are examples in the literature of expression patterns of some of the receptors at specific stages of cochlear development there has been no systematic study. We have assembled a full analysis of the patterns of receptor expression during cochlear development for all four Fgfrs using in situ hybridization. We have analyzed the expression patterns from embryonic day 13.5 through postnatal ages. We find that Fgfr1, 2, and 3 are expressed in the epithelium of the cochlear duct and Fgfr4 is limited in its expression to the mesenchyme surrounding the duct. We compare the receptor expression pattern to markers of the sensory domain (p27kip1) and the early hair cells (math1).

References

Jan 1, 1985·Acta Oto-laryngologica. Supplementum·D J Lim, M Anniko
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·U PirvolaJ Ylikoski
Feb 1, 1993·Developmental Biology·K PetersL Williams
Mar 29, 2001·Genome Biology·D M Ornitz, N Itoh
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·M Ford-PerrissM Murphy
May 23, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sarah PauleyBernd Fritzsch
Jun 18, 2003·Development·Tracy J Wright, Suzanne L Mansour
Oct 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tracy J WrightSuzanne L Mansour
Nov 19, 2003·Development·Yolanda AlvarezThomas Schimmang
Oct 12, 2004·Trends in Genetics : TIG·Nobuyuki Itoh, David M Ornitz
Mar 3, 2005·Genes & Development·Raj K LadherGary C Schoenwolf
Apr 7, 2006·The Journal of Biological Chemistry·Xiuqin ZhangDavid M Ornitz
Nov 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Toshinori HayashiOlivia Bermingham-McDonogh
Jun 9, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chandrakala PuligillaMatthew W Kelley
Jul 20, 2007·Development·Bonnie E JacquesMatthew W Kelley
Sep 25, 2007·The International Journal of Developmental Biology·Takahiro OhyamaKareen Martin
Dec 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nobuyuki Itoh, David M Ornitz
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toshinori HayashiOlivia Bermingham-McDonogh
Sep 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ekaterina P HatchSuzanne L Mansour
Sep 27, 2008·Human Molecular Genetics·Suzanne L MansourAndrew O M Wilkie

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Citations

Dec 22, 2011·Development·Andrew K Groves, Donna M Fekete
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vidhya MunnamalaiOlivia Bermingham-McDonogh
Apr 3, 2012·Hearing Research·Dyan RamekersSjaak F L Klis
Mar 29, 2011·American Journal of Otolaryngology·Bryony A Nayagam, Ricki L Minter
Jan 28, 2015·Developmental Biology·Lisa D UrnessSuzanne L Mansour
Jun 2, 2015·Cell Reports·Jörg WaldhausStefan Heller
Dec 3, 2014·International Journal of Pediatric Otorhinolaryngology·Nneamaka B AgochukwuMaximilian Muenke
Jun 29, 2016·PloS One·Sang Goo LeeZheng-Yi Chen
Oct 1, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vidhya Munnamalai, Donna M Fekete
Aug 1, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yutao SuDavid M Ornitz
Sep 1, 2017·BMB Reports·Michael Ebeid, Sung-Ho Huh

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