Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and beta-catenin in a malignant pilomatricoma: a histological and immunohistochemical study

Journal of Cutaneous Pathology
Bernard CribierJürgen Schweizer

Abstract

We have previously shown that benign pilomatricomas not only maintain the sequential expression of the hair matrix and precortex keratins hHa5 and hHa1 of normal hair follicles in their transitional cell compartment, but also preserve the association of hHa5 expression with that of its regulatory homeoprotein HOXC13 in the lower transitional cell compartment. In contrast, hHa1 expression in the upper transitional cell compartment is uncoupled from the nuclear co-expression of the LEF1/beta-catenin complex seen in normal hair follicles (Cribier et al., J Invest Dermatol 2004; 122: 1078). Formalin-fixed paraffin sections of the tumor were examined using a panel of mono- and polyclonal hair and epithelial keratin antibodies as well as antibodies against HOXC13, LEF1, and beta-catenin. Morphologically, the malignant pilomatricoma investigated here clearly deviated from the described major tumor type by a large number of differently sized parakeratotic squamoid whorls emerging within the mass of basaloid cells and surrounded by cells remembering transitional cells, but only rarely containing shadow cells and signs of calcification. We show that hHa5/HOXC13 co-expression was maintained in transitional cell areas, in which hHa1 expres...Continue Reading

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Citations

May 8, 2008·Histochemistry and Cell Biology·Roland MollLutz Langbein
Mar 29, 2014·Journal of Cutaneous Pathology·Maxime BattistellaBernard Cribier
Apr 18, 2014·Journal of the American Academy of Dermatology·Jennifer L HerrmannMichael B Morgan
Dec 17, 2014·Human Pathology·Elizabeth A BilodeauRaja R Seethala
Jan 26, 2018·Journal of Cutaneous Pathology·Katherine Tumminello, Gregory A Hosler
Oct 4, 2017·Diagnostic Cytopathology·Alessandra C SchmittMomin T Siddiqui
Dec 9, 2010·Rare Tumors·Alejandro Peralta SolerJames L Burchette
May 24, 2007·Journal of Cutaneous Pathology·Alejandro Peralta SolerJohn A Olson
May 22, 2010·The American Journal of Dermatopathology·Elzbieta A SlodkowskaJ Andrew Carlson
Oct 18, 2019·Journal of Cutaneous Pathology·Cem LeblebiciCuyan Demirkesen
Aug 15, 2015·The American Journal of Dermatopathology·Gabriel VilladaPaolo Romanelli
May 30, 2019·Cancers·Gerardo BottiMonica Cantile

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