PMID: 20132732Feb 6, 2010Paper

Expression patterns of PRDM10 during mouse embryonic development

BMB Reports
Jin-Ah Park, Keun Cheol Kim

Abstract

It is well known that PR/SET family members participate in transcriptional regulation via chromatin remodeling. PRDM10 might play an essential role in gene expression, but no such evidence has been observed so far. To assess PRDM10 expression at various stages of mouse development, we performed immunohistochemistry using available PRDM10 antibody. Embryos were obtained from three distinct developmental stages. At E8.5, PRDM10 expression was concentrated in the mesodermal and neural crest populations. As embryogenesis proceeded further to E13.5, PRMD10 expression was mainly in mesoderm-derived tissues such as somites and neural crest-derived populations such as the facial skeleton. This expression pattern was consistently maintained to the fetal growth period E16.5 and adult mouse, suggesting that PRDM10 may function in tissue differentiation. Our study revealed that PRDM10 might be a transcriptional regulator for normal tissue differentiation during mouse embryonic development. [BMB reports 2010; 43(1): 29-33].

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Citations

Sep 1, 2012·Science·Matthias MeyerSvante Pääbo
Dec 22, 2015·Trends in Endocrinology and Metabolism : TEM·Jingyi Chi, Paul Cohen
May 24, 2011·Proteins·Klára BriknarováTara E Ness
Feb 26, 2014·Biochemical and Biophysical Research Communications·Hee-Jung NohKeun-Cheol Kim
Feb 19, 2015·Cytotechnology·Rieko EguchiKosuke Tashiro
Dec 21, 2018·The American Journal of Surgical Pathology·Florian PulsFredrik Mertens
Jul 18, 2019·The Journal of Pathology·Jakob HofvanderFredrik Mertens
Oct 27, 2015·Neural Development·Denise A Zannino, Charles G Sagerström
Jun 13, 2019·Scientific Reports·Martin Kuhlwilm, Cedric Boeckx
Jul 19, 2020·Nature Communications·Brenda Y HanErnesto Guccione
Oct 27, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Cathrine K FogAnders H Lund
Nov 4, 2020·Brain : a Journal of Neurology·Antonio C Fuentes-FayosRaúl M Luque
Jun 7, 2012·Development·Tobias Hohenauer, Adrian W Moore

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