Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.

Cancer Gene Therapy
Yao FanJian Guan

Abstract

COMMD10, a member of COMMD protein, has been proved to target p65 NF-kappaB (nuclear factor-kappaB) subunit and reduce its nuclear translocation, thereby leading to the inactivation of NF-kappaB pathway and suppression of colorectal cancer invasion and metastasis. The aim of this study is to explore its expression pattern and tissue distribution in human normal tissues and other tumor tissues and to investigate the relevant mechanism. We firstly provided the expression profile and histological distribution of COMMD10 in various BALB/c mice tissues and identified the biological distribution of COMMD10 in different kinds of human normal and tumor tissues. We verified the expression profile of COMMD10 using TCGA database. The interacting genes of COMMD10 were predicted by using STRING using. Finally, we performed database, and the microRNAs targeting COMMD10 were predicted using miRDB, miRWalk, TargetScan and microRNA. GO and KEGG pathway analyses were performed to predict the biological function of COMMD10 and its interacting genes. mRNA expression of COMMD10 showed the highest level in the lung and spleen, and the lowest level in the heart and brain. Immunohistochemistry detection revealed that COMMD10 was expressed in different...Continue Reading

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Methods Mentioned

BETA
surgical resection
reverse transcription PCR
Assay
PCR
RNA Assay
aminoacylation
nuclear translocation
ubiquitination

Software Mentioned

Xena browser
TargetScan
R2
SPSS
DAVID ( Database for Annotation , Visualization and Integrated...
STRING Tool for the
Cytoscape
DAVID
miRWalk
cBioPortal

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