Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus

Endocrine Journal
Huiyan WangBin Yu

Abstract

Forty-five pregnant women who underwent cesarean section, including 30 cases of gestational diabetes mellitus (GDM) and 15 normal pregnant women, were enrolled in this study to examine the differential expression of circular RNAs (circRNAs) in the placentas of women with GDM by RNA sequencing (RNA-seq) analysis. The differentially expressed circRNAs were analyzed bioinformatically using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and circRNA-microRNA (miRNA) interaction prediction. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the results. A total of 8,321 circRNAs were identified in the human placenta, among which 46 were differentially expressed (fold change ≥2 and p < 0.05), including three that were upregulated and 43 that were downregulated. According to the GO and KEGG enrichment results, these circRNAs may be associated with vital biological processes, cellular components, molecular functions, and signaling pathways. In particular, KEGG analysis shown they may be involved in advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications, indicating that these circRNAs might participate...Continue Reading

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Citations

Nov 7, 2019·International Journal of Molecular Sciences·Mirza Muhammad Fahd QadirRicardo Luis Pastori
Oct 13, 2020·Human Reproduction Update·Hannah E J Yong, Shiao-Yng Chan
Jan 5, 2021·Frontiers in Bioengineering and Biotechnology·Yuxin RanHongbo Qi
Oct 28, 2020·Reviews in Endocrine & Metabolic Disorders·Maleesa M PathiranaPrabha H Andraweera
May 27, 2021·Journal of Applied Toxicology : JAT·Yanru ZhaoBingchen Liu
Jun 5, 2021·Archives of Physiology and Biochemistry·Sadra Samavarchi TehraniReza Meshkani
Jun 13, 2021·Ageing Research Reviews·Yang YangYe Tian
Aug 31, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Runyu DuLing Li

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