Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
D RostamzadehZ Amirghofran

Abstract

Recently identified Fc receptor-like (FCRL) molecules are new members of the immunoglobulin superfamily dominantly expressed by B cells. Although FCRL expression patterns have been studied in normal and malignant cells, their biological functions and roles remain to be clearly identified in humans. Research has particularly focused on FCRL gene polymorphisms in autoimmune diseases, however, their involvement in the pathogenesis of autoimmune diseases is an interesting field for investigation. In the present study, we have investigated the gene expression profiles of FCRL1, 2, and 4 in 2 common thyroid diseases, Hashimoto's thyroiditis (HT) and Graves' disease (GD). FCRL1, 2, and 4 expressions were determined in peripheral blood samples of 55 HT patients, 40 GD patients and equal numbers of normal subjects by quantitative real-time PCR. Our results showed downregulation of FCRL1 and upregulation of FCRL2 transcripts in both HT and GD groups compared to healthy counterparts. Overexpression of FCRL4 was observed only in GD patients compared to controls. A significant correlation was observed between all FCRL gene expression levels in HT patients. Only FCRL2 and 4 had a correlation in GD patients. In addition, FCRL1, 2, and 4 gene ...Continue Reading

Citations

May 20, 2016·Rheumatology International·Ali KhanzadehZahra Amirghofran
May 9, 2018·Expert Opinion on Therapeutic Targets·Davood RostamzadehMahdi Shabani
Jul 28, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Ghazal AtaabadiNima Montazeri-Najafabady
Jan 17, 2020·European Journal of Clinical Investigation·Ioannis KyrgiosAssimina Galli-Tsinopoulou
Oct 9, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Yonghui YangTianbo Jin

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