Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Nimesh GuptaP V Lakshmana Rao

Abstract

Host immune response particularly through the induction of proinflammatory cytokines and chemokines in Japanese encephalitis virus infection has not been clearly understood in relation with pathogenicity and disease severity. The newly identified host mediators of pathogenesis could be the future target for diagnostic and therapeutics purpose. We investigated the mechanism of JE virus induced pathogenesis in terms of proinflammatory cytokine and chemokine secretion at molecular level in young one-week-old BALB/c mouse after subcutaneous administration of JEV. Histopathology of brain was done to observe the morphological changes after JEV infection and genes relevant to macrophage activation, chemokine secretion, inflammatory cell infiltration, and blood-brain barrier permeability were examined at their gene and protein expression level for various time points after infection. At 6-day post-infection 100% mortality was observed. At 5-day post-infection, there was a robust expression of proinflammatory cytokines and chemokines with increased number of infiltrating inflammatory cells into the brain. Histopathology data confirms the infiltration of leucocytes and there was a marked upregulation in expression of genes relevant to in...Continue Reading

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Citations

Mar 5, 2011·Virology Journal·Nimesh Gupta, P V Lakshmana Rao
Jan 24, 2014·BioMed Research International·Ravi Kant Upadhyay
Jul 22, 2014·Micron : the International Research and Review Journal for Microscopy·Mukesh Saraswat, K V Arya
Feb 5, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xin-Feng LiPu-Yan Chen
Mar 1, 2011·Neurochemistry International·Chun-Jung ChenChen-Jung Chang
Dec 21, 2010·Neurochemistry International·Chun-Jung ChenShih-Yun Chen
Apr 10, 2013·European Journal of Immunology·Maximilian LarenaMario Lobigs
Jun 21, 2019·Cells·Fabio Seiti Yamada YoshikawaLuanda Mara da Silva Oliveira
Apr 21, 2021·Journal of Neurovirology·Sambor GrygorczukAnna Moniuszko-Malinowska
Jul 19, 2021·Molecular Aspects of Medicine·Kiran Bala SharmaManjula Kalia
Sep 22, 2021·The Journal of General Virology·Kiran Bala SharmaManjula Kalia

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