Expression profile of polyunsaturated fatty acids in colorectal cancer

World Journal of Gastroenterology : WJG
Kai YangChang-Zheng Wang

Abstract

To investigate the relationship between the metabolism of polyunsaturated fatty acids (PUFAs) and tumor-associated factors for predicting the outcome of colorectal carcinoma (CRC) in Chinese patients. Fresh-frozen malignant and normal tissues from 82 Chinese patients with CRC were analyzed for PUFA composition using gas-liquid chromatography. The levels of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), prostaglandin E2 and platelet-derived growth factor (PDGF) were measured by enzyme-linked immunosorbent assay, and the levels of VEGF, p53 and Ki-67 were measured by immunohistochemistry. In malignant tissue, compared with normal tissue, the levels of total ω-6 PUFAs (24.64%±3.41% vs 26.77%±3.37%, P=0.00) and linoleic acid (LA) (15.46%±3.51% vs 18.30%±2.83%, P<0.01) were lower, whereas the levels of total ω-3 PUFAs (1.58%±0.74% vs 1.35%±0.60%, P<0.01) and dihomo-gamma-linolenic acid (DGLA) (1.32%±0.69% vs 0.85%±0.29%, P<0.01) were significantly higher. The ratios of arachidonic acid (AA)/LA (0.53±0.22 vs 0.42±0.19, P<0.01) and AA/total ω-6 PUFAs (0.31±0.09 vs 0.27±0.10, P<0.01) were also significantly higher in malignant tissue. The levels of PDGF (353.10±148.85 pg/mL vs 286.09±104.91 pg/mL, P<0.01), COX-2 (12...Continue Reading

References

Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·B Armstrong, R Doll
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E J CoreyJ R Cashman
Nov 27, 1999·Pharmacology & Therapeutics·D P Rose, J M Connolly
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·M StolinaS M Dubinett
Mar 7, 2003·The New England Journal of Medicine·John A BaronRosalind U van Stolk
May 26, 2004·The American Journal of Clinical Nutrition·Susanna C LarssonAlicja Wolk
Aug 24, 2004·Oncogene·Marjorie L McCullough, Edward L Giovannucci
Nov 17, 2004·Mini Reviews in Medicinal Chemistry·Rafat A SiddiquiGary P Zaloga
Mar 26, 2005·BMC Biochemistry·Jing X Kang, Jingdong Wang
Sep 10, 2005·World Review of Nutrition and Dietetics·Artemis P Simopoulos
Jun 8, 2006·Journal of the National Cancer Institute·Sun-Jin KimIsaiah J Fidler
Sep 1, 2006·The New England Journal of Medicine·Monica M BertagnolliUNKNOWN APC Study Investigators
Sep 1, 2006·The New England Journal of Medicine·Nadir ArberUNKNOWN PreSAP Trial Investigators
Oct 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Simopoulos
Dec 22, 2006·The Journal of Nutrition·Robert S ChapkinDavid N McMurray
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan N HallJing Ma
Aug 28, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jonathan HimmelfarbGuy Miller
Mar 19, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P D TsitourasS M Harman
Sep 9, 2008·Trends in Molecular Medicine·Hedi HariziNorbert Gualde
Feb 3, 2009·Clinical Chemistry·Javier A MenendezJose Manuel Fernandez-Real
May 5, 2009·Virchows Archiv : an International Journal of Pathology·Tsuguhiko SeoChoitsu Sakamoto
Jun 6, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laura SpencerAshley Dennison
Sep 8, 2009·Experimental and Molecular Pathology·Javier de CastroJesús Sánchez-Yagüe
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul L NguyenMassimo Loda

❮ Previous
Next ❯

Citations

Mar 5, 2016·World Journal of Gastroenterology : WJG·He-Jin JiaYa-Ping Tian
Oct 22, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Charles A PickensJenifer I Fenton
Jun 4, 2020·Cancers·Lidia Sánchez-AlcoholadoMaría Isabel Queipo-Ortuño
Sep 21, 2018·Frontiers in Oncology·Lígia A B M MendonçaCristiano M E Carvalho
Jan 28, 2019·Lipids in Health and Disease·Alicja PakietAdriana Mika
Feb 8, 2020·Scientific Reports·Adriana MikaTomasz Sledzinski
Oct 27, 2018·Current Cancer Drug Targets·Gang WangXing-Li Fu
Jul 3, 2021·International Journal of Molecular Sciences·Kamila P LiputMariusz Pierzchała

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.