Expression profile of the S100 gene family members in oral squamous cell carcinomas

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Dipak SapkotaSalah Osman Ibrahim

Abstract

Several of the S100 gene members have been reported to be differentially expressed in many human pathological conditions, in particular, the malignancies. Identification and quantification of the differentially expressed S100 gene members in oral squamous cell carcinoma (OSCC) might facilitate their use as potential diagnostic and/or prognostic markers or targets for therapy. we examined the expression profile of 16 members of the S100 gene family at the mRNA level by semiquantitative reverse transcription-polymerase chain reaction (sRT-PCR) in 27 cases of OSCCs/their pair-wised normal controls obtained from Sudanese patients, and confirmed the sRT-PCR results by performing quantitative real time-polymerase chain reaction (qRT-PCR) for 6 of the 16 genes examined. With sRT-PCR, 4 (25%; S100A4, S100A6, S100A8, S100A14) out of the 16 S100 gene members examined were found to be significantly down-regulated (P < 0.05) in the tumors compared to the normal controls. None of the S100 gene members examined were found to be significantly up-regulated in the tumors. qRT-PCR results confirmed the significant down-regulation of the S100A4, S100A6, and S100A14 genes in the tumors examined. S100 gene family members might play an important rol...Continue Reading

References

Apr 4, 1995·Biochimica Et Biophysica Acta·E TulchinskyE Lukanidin
Nov 15, 1995·International Journal of Cancer. Journal International Du Cancer·A M IdrisM O Malik
Apr 10, 1995·International Journal of Cancer. Journal International Du Cancer·A M IdrisE I el-Beshir
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D T WongR B Donoff
May 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G N BertaF Di Carlo
Apr 7, 1999·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·C W Heizmann, J A Cox
Aug 18, 2000·Life Sciences·L F FungS W Tsao
Oct 21, 2000·Molecular Pathology : MP·H K Williams
Jul 21, 2001·The Journal of Biological Chemistry·I S ThoreyS Werner
Jan 24, 2002·The Journal of the American Dental Association·S Silverman
Feb 22, 2002·The Journal of Pathology·Barry R DaviesJ Kilian Mellon
May 7, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Claus W HeizmannBeat W Schäfer
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sanjay GuptaHasan Mukhtar
Mar 20, 2003·Microscopy Research and Technique·Rosario Donato
Jul 31, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yong Gu ChoWon Sang Park
Mar 10, 2004·Oral Oncology·Makiko Moriyama-KitaEtsuhide Yamamoto
Jun 9, 2004·Journal of Cancer Research and Clinical Oncology·Junfang JiZhihua Liu
Jul 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ethan D EmberleyPeter H Watson
Mar 24, 2005·Cancer Metastasis Reviews·Lajos Döbrossy
Mar 29, 2005·Oral Oncology·Sen-Tien TsaiLi-Wha Wu
Apr 12, 2005·European Journal of Cell Biology·Mariana Roesch ElyFranz X Bosch
May 19, 2005·British Journal of Cancer·D M HelfmanM Grigorian
Jun 16, 2005·Molecular Cancer Therapeutics·Abhijit G BanerjeeJamboor K Vishwanatha
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander HermaniDoris Mayer
Aug 13, 2005·World Journal of Gastroenterology : WJG·Yong-Gu ChoWon-Sang Park
Oct 26, 2005·The Journal of Biological Chemistry·Sarah C GarrettAnne R Bresnick
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenoki OhuchidaMasao Tanaka
Nov 22, 2005·Cancer Letters·Makiko Moriyama-KitaTakuma Sasaki
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bjarte DysvikSalah O Ibrahim
Apr 15, 2006·Journal of Surgical Oncology·A K HemandasC K Leow
May 11, 2006·The Biochemical Journal·Liliana Santamaria-KisielGary S Shaw
Jul 13, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·João MassanoArtur Ferreira
Jul 19, 2006·Biochemical Pharmacology·Christoffer GebhardtJochen Hess
Aug 15, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A A K FolgueiraM M Brentani
Aug 16, 2006·Molecular Cancer Research : MCR·Wan-Chi TsaiLi-Wha Wu
May 15, 2007·The Journal of Investigative Dermatology·Wiesława LeśniakJacek Kuźnicki

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Citations

Aug 7, 2010·PloS One·Satyendra Chandra TripathiK W Michael Siu
May 7, 2014·Clinical & Experimental Metastasis·Marcos Vinícius Macedo de OliveiraAlfredo Maurício Batista De-Paula
Dec 11, 2013·Nucleic Acids Research·Chien-Hua PengWen-Ping Hsieh
Jan 5, 2011·Digestive Diseases and Sciences·Anastassios C ManolakisSpyros P Potamianos
May 28, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Jen JouCheng-Wen Lin
Dec 17, 2009·Connective Tissue Research·Patrizia CancemiIda Pucci-Minafra
Nov 16, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Dipak SapkotaSalah O Ibrahim
Jul 25, 2009·European Journal of Oral Sciences·Bina RajuKarin J Heyeraas
Oct 26, 2011·Archives of Oral Biology·Gabriela Dabija-WolterDaniela E Costea
Oct 29, 2011·Oral Oncology·Dipak SapkotaSalah O Ibrahim
Aug 24, 2016·Journal of Periodontal Research·Y-S L ChengT Rees
May 21, 2019·Oncotarget·Suyog BasnetDipak Sapkota
Feb 15, 2018·Journal of Dental Research·P P ArgyrisM C Herzberg

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