Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein

International Journal of Andrology
Hiromitsu TanakaYoshitake Nishimune

Abstract

Recently we cloned the Hanp1 cDNA that encodes a histone H1-like haploid germ cell-specific nuclear protein in the mouse. Homozygous Hanp1 mutant male mice were infertile, while females were fertile. Although a substantial number of sperm were recovered from the epididymis, their shape and function were abnormal. Hanp1 protein is essential for nuclear formation in functional spermatozoa, and is specifically involved in the replacement of histones with protamines during spermiogenesis. To investigate the roles of human HANP1 (h-HANP1) and its relation to male infertility, we isolated h-HANP1 cDNA from a human cDNA plasmid library using mouse Hanp1 cDNA as a probe. h-HANP1 is expressed in the testes and its genomic construct also intronless as mouse Hanp1. We found that the h-HANP1 coding region have 5 single-nucleotide polymorphisms in Japanese men.

References

Nov 14, 1998·Seminars in Cell & Developmental Biology·P Sassone-Corsi
Feb 6, 2003·Molecular Human Reproduction·Hiromitsu TanakaYoshitake Nishimune
Jan 1, 2004·The Journal of Biological Chemistry·Ilias MylonisThomas Giannakouros
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Igor MartianovIrwin Davidson
Feb 22, 2005·Cellular and Molecular Life Sciences : CMLS·H Tanaka, T Baba
Jun 16, 2005·Journal of Andrology·Kouichi KitamuraHiromitsu Tanaka
Aug 2, 2005·Molecular and Cellular Biology·Hiromitsu TanakaYoshitake Nishimune

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Citations

Aug 16, 2013·Nucleic Acids Research·Sean W HarshmanMichael A Freitas
Dec 6, 2011·Asian Journal of Andrology·Annelien MassartKatrien Stouffs
Dec 8, 2007·Reproductive Biomedicine Online·Frank TüttelmannManuela Simoni
May 3, 2013·Systems Biology in Reproductive Medicine·Bahar BehrouziClifford L Librach
Sep 10, 2013·Journal of Proteomics·Sean W HarshmanMichael A Freitas
Jan 9, 2007·Human Reproduction Update·Douglas T CarrellSue Hammoud
Jun 12, 2010·Systems Biology in Reproductive Medicine·Susan TamowskiDouglas T Carrell
Jan 18, 2017·Epigenetics & Chromatin·Sara El KennaniJérôme Govin
Jul 16, 2021·Reproductive Medicine and Biology·Hiromitsu Tanaka, Akira Tsujimura

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