Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas

OncoTargets and Therapy
Dan CongHui Sun

Abstract

In the present study, we analyzed microRNA (miRNA) and gene expression profiles using 499 papillary thyroid carcinoma (PTC) samples and 58 normal thyroid tissues obtained from The Cancer Genome Atlas database. A pivotal regulatory network of 18 miRNA and 16 targets was identified. Upregulated miRNAs (miR-222, miR-221, miR-146b, miR-181a/b/d, miR-34a, and miR-424) and downregulated miRNAs (miR-9-1, miR-138, miR-363, miR-20b, miR-195, and miR-152) were identified. Among them, the upregulation of miR-424 and downregulation of miR-363, miR-195, and miR-152 were not previously identified. The genes CCNE2 (also known as cyclin E2), E2F1, RARA, CCND1 (cyclin D1), RUNX1, ITGA2, MET, CDKN1A (p21), and COL4A1 were overexpressed, and AXIN2, TRAF6, BCL2, RARB, HSP90B1, FGF7, and PDGFRA were downregulated. Among them, CCNE2, COL4A1, TRAF6, and HSP90B1 were newly identified. Based on receiver operating characteristic curves, several miRNAs (miR-222, miR-221, and miR-34a) and genes (CCND1 and MET) were ideal diagnostic indicators, with sensitivities and specificities greater than 90%. The combination of inversely expressed miRNAs and targets improved diagnostic accuracy. In a clinical feature analysis, several miRNAs (miR-34a, miR-424, miR-20...Continue Reading

Citations

Apr 1, 2014·Gynecologic Oncology·John K ChanDaniela Matei
May 8, 2019·International Journal of Molecular Sciences·Magdalena RudzińskaBarbara Czarnocka
May 17, 2018·Molecular Medicine Reports·Yi GuTong Liu
Sep 5, 2017·European Thyroid Journal·Mohammad-Reza Mahmoudian-SaniGholam-Reza Mobini
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Xiangdong LiuYingjie Wu
Apr 24, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H ZhangH Ding
Jun 3, 2021·Journal of Clinical Medicine·Katarzyna Wieczorek-Szukala, Andrzej Lewinski

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Methods Mentioned

BETA
biopsy

Software Mentioned

TargetScan
SAM ( Significance Analysis of Microarrays )
SPSS
MedCalc

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