Expression Profiling Analysis Reveals Key MicroRNA-mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa

Investigative Ophthalmology & Visual Science
Ander AnasagastiJavier Ruiz-Ederra

Abstract

The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease. miRNAs-mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration. Of more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a significant differential expression in rd10 retinas compared with control samples and (2) an inverse expression relationship with predicted mRNA targets involved in biological pathways relevant to retinal biology and/or degeneration. Seven of the selected miRNAs have been associated with retinal dystrophies, whereas, to our knowledge, nine have not been previously linked to any disease. This study contributes to our understanding of the etiology and progression of retinal degeneration.

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Citations

Nov 28, 2018·Investigative Ophthalmology & Visual Science·Zhi-Peng YouKe Shi
Mar 3, 2020·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kenji SakamotoTsutomu Nakahara
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Feb 5, 2021·Frontiers in Cell and Developmental Biology·Sabrina CarrellaMarianthi Karali
Feb 16, 2021·Frontiers in Pharmacology·Alessandra MiceraMarco Coassin
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Jul 6, 2021·Frontiers in Cell and Developmental Biology·Sabrina CarrellaAlessia Indrieri
Sep 30, 2021·International Ophthalmology Clinics·Michael T Massengill, Alfred S Lewin

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Methods Mentioned

BETA
PCR

Software Mentioned

CytoScape
DAVID
miRanda
miRWalk
WikiPathways
TargetScan
ClueGO
Expression Console
ClueGO app

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