Expression profiling of G2/M phase regulatory proteins in normal, premalignant and malignant uterine cervix and their correlation with survival of patients

Journal of Cancer Research and Therapeutics
ChhaviM L B Bhatt

Abstract

Cell regulatory G2/M phase proteins are the key regulators of mitosis and have been reported with abnormal expressions in various malignancies. To determine the expressions of these proteins in neoplastic uterine cervix tissue. This study evaluates the G2/M phase regulatory protein expression of Cyclin B1, Aurora-B, Pololike kinase 1 (PLK1) and LIM kinase1 (LIMK1) in tissues of 25 normal (control), 16 dysplastic (dysplasia) and 34 neoplastic (cancer) patients of uterine cervix. The expressions of different proteins were obtained by using Western Blot technique. One way analysis of variance (ANOVA), Pearson correlation, Kaplan-Meier and other tests are used for analysis. The level of expression of LIMK1 in cervical cancer patients was found to be significantly higher (P < 0.01) than both the controls and dysplasia. The expression of Aurora B and PLK1 in cervical cancer patients was also found to be significantly higher ( P < 0.05) than controls but it did not differ with dysplasia. However, the expression of Cyclin B1 was similar among cervical cancer patients, dysplasia and controls ( P> 0.05). The expression of all the above proteins showed significant ( P < 0.01) and inverse relation with the survival of cancer patients. Amon...Continue Reading

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Nov 15, 2011·Clinical and Experimental Medicine·Julia A PezukLuiz G Tone
Nov 20, 2014·Cytometry. Part B, Clinical Cytometry·Yu-Wen LinE-Jian Lee
Aug 26, 2014·Expert Opinion on Therapeutic Targets·Jaime BerumenIngrid Medina
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Sep 16, 2015·PloS One·Eira Valeria BarrónJaime Berumen

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