Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb

Scientific Reports
Ming WangLuo Zhang

Abstract

Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanisms underlying this impairment remain unclear. In the current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) and long non-coding RNAs (lncRNAs) in OBs from three groups of mice of different ages (2 months-old young adults, 6 months-old mature adults and 20 months-old aged adults), for their potential roles in olfactory impairment. Gene Ontology and pathway analysis results showed that the differentially expressed PCGs in the OBs from aged mice were mainly associated with signal transduction, regulation of gene expression and cellular microenvironment. Similarly, gene set enrichment analysis identified two differentially and inversely expressed lncRNAs (NONMMUT004524 and NONMMUT000384), both of which were significantly associated with neuroactive ligand-receptor interaction pathway in the OBs of aged mice. These findings suggest that a decline of olfactory function in aged mice may be linked to di...Continue Reading

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Citations

Apr 17, 2019·Journal of Applied Physiology·Anthony J SannicandroKatarzyna Goljanek-Whysall
May 11, 2019·Calcified Tissue International·Yu ZhouHong-Wen Deng
Nov 3, 2020·RNA Biology·Tal Koffler-BrillKaren B Avraham

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

BioCyc
Reactome
cluster
DAVID
Panther
Affymetrix
Expression Console
Significance Analysis of Microarrays ( SAM )
SPSS
SAM

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