Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis

Acta Oto-laryngologica
Weiliang BaiHong Gao

Abstract

Down-regulation of metastasis inhibitor genes PTEN and thrombospondin 2 may play a role in the lymphatic metastasis of supraglottic carcinoma. To investigate differentially expressed genes in supraglottic squamous cell carcinoma with and without lymphatic metastasis using cDNA microarray. cDNA microarray was used to detect the expression profiles of supraglottic carcinoma and the results were validated with real-time PCR. Compared with normal laryngeal tissues, the expression of 15.6% (15/96) genes including cathepsin B, cathepsin D, cathepsin L, Ets1, c-Ets2, and PEA3 were up-regulated in both cases of supraglottic carcinoma. Compared with the supraglottic carcinoma with no lymph node metastasis, the expression of metastasis inhibitor genes PTEN and thrombospondin 2 was down-regulated in the supraglottic carcinoma tissue with lymph node metastasis.

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Citations

Sep 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Anna Del PreteCarmelina Loguercio
Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun WangZengjun Wang
Nov 16, 2012·Journal of Experimental & Clinical Cancer Research : CR·Xiao-Lin ZhuWei-Ping Wen
Jan 17, 2020·Journal of Cellular Biochemistry·Chunjue YuanYunbao Pan
Apr 15, 2019·Experimental and Molecular Pathology·Hongxiang FengDeruo Liu

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