Abstract
Down-regulation of metastasis inhibitor genes PTEN and thrombospondin 2 may play a role in the lymphatic metastasis of supraglottic carcinoma. To investigate differentially expressed genes in supraglottic squamous cell carcinoma with and without lymphatic metastasis using cDNA microarray. cDNA microarray was used to detect the expression profiles of supraglottic carcinoma and the results were validated with real-time PCR. Compared with normal laryngeal tissues, the expression of 15.6% (15/96) genes including cathepsin B, cathepsin D, cathepsin L, Ets1, c-Ets2, and PEA3 were up-regulated in both cases of supraglottic carcinoma. Compared with the supraglottic carcinoma with no lymph node metastasis, the expression of metastasis inhibitor genes PTEN and thrombospondin 2 was down-regulated in the supraglottic carcinoma tissue with lymph node metastasis.
References
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·M Detmar
Mar 22, 2003·Lancet·Norio IizukaYoshihiko Hamamoto
May 10, 2003·The Journal of Biological Chemistry·Xin A ZhangLi Liu
Mar 17, 2004·Archives of Otolaryngology--head & Neck Surgery·Cecelia E SchmalbachSamir Hanash
Mar 9, 2005·The Journal of Medical Investigation : JMI·Toshiyuki Nomura, Nobuhiko Katunuma
Apr 1, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jan Akervall
May 16, 2006·Journal of Clinical Pathology·Huachuan ZhengYasuo Takano
Jul 27, 2006·Human Pathology·Kazuhira EndoTomokazu Yoshizaki
Mar 8, 2007·Carcinogenesis·Carmen Blanco-AparicioAmancio Carnero
Mar 16, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Denghai MiXingrui Li
Apr 3, 2007·Neoplasia : an International Journal for Oncology Research·Jingbo QiaoDai H Chung
May 4, 2007·Molecular Cancer Research : MCR·Karen D Cowden DahlLaurie G Hudson
Aug 28, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·N Fazil ErdemAlbert T Ichiki
Oct 9, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li ZhuW C Chow Louis
Nov 6, 2007·Gynecologic Oncology·William H BradleyLevi S Downs
Nov 7, 2007·The Journal of Pathology·B S ParkerR L Anderson
Nov 22, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jian-Min YangZai-Yuan Ye
Jan 25, 2008·Journal of Cell Science·Sarah M PlanchonCharis Eng
Citations
Oct 21, 2011·DNA and Cell Biology·Xian-Dong LinJian-Yin Lin
Sep 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Anna Del PreteCarmelina Loguercio
Oct 12, 2010·Journal of Cell Science·Priyadharsini NagarajanLee Ann Garrett-Sinha
Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun WangZengjun Wang
Nov 16, 2012·Journal of Experimental & Clinical Cancer Research : CR·Xiao-Lin ZhuWei-Ping Wen
Apr 26, 2014·Head & Neck·Rob NoorlagRobert J J van Es
Jul 12, 2014·Acta Oto-laryngologica·Hongzhi MaJugao Fang
Jun 16, 2015·Molecular BioSystems·Qing-yong ChenJian-guo Shi
Nov 13, 2012·The American Journal of Pathology·Dandan LiMing Liu
Jan 17, 2020·Journal of Cellular Biochemistry·Chunjue YuanYunbao Pan
Apr 15, 2019·Experimental and Molecular Pathology·Hongxiang FengDeruo Liu