Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene

FEBS Letters
Makoto SaitoShinya Watanabe

Abstract

Gene amplification is a major genetic alteration in human cancers. Amplicons, amplified genomic regions, are believed to contain "driver" genes responsible for tumorigenesis. However, the significance of co-amplified genes has not been extensively studied. We have established an integrated analysis system of amplicons using retrovirus-mediated gene transfer coupled with a human full-length cDNA set. Applying this system to 17q12-21 amplicon observed in breast cancer, we identified GRB7 as a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt. Our work provides an insight into the biological significance of gene amplification in human cancers.

References

Jul 10, 1987·Science·P P Di FioreS A Aaronson
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Jan 22, 2004·Molecular Biotechnology·Imen RabhiDahmani M Fathallah
Apr 21, 2005·European Biophysics Journal : EBJ·Corrine J PorterJackie A Wilce
Apr 8, 2006·Endocrine-related Cancer·P Kauraniemi, A Kallioniemi
Oct 6, 2007·Carcinogenesis·Tao Bai, Shiuh-Wen Luoh
Mar 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·David S HsuAnil Potti
Dec 24, 2009·Nature Reviews. Cancer·Thomas SantariusColin S Cooper

❮ Previous
Next ❯

Citations

May 1, 2013·Biochimica Et Biophysica Acta·William JacotPierre-Jean Lamy
Mar 16, 2017·Journal of Molecular Recognition : JMR·Malika P GodamudunageBarbara A Lyons
Jul 30, 2019·Journal of Molecular Recognition : JMR·Andrew M BradfordBarbara A Lyons
Jul 17, 2019·Molecular & Cellular Proteomics : MCP·Pamela WuJianjiong Gao
Mar 6, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·William W BivinUma Krishnamurti
Dec 2, 2014·Biomolecular Concepts·Atsuka MatsuiKentaro Semba
Jan 7, 2019·Breast Cancer Research : BCR·Hiroaki TagayaKentaro Semba
Oct 26, 2018·Molecular Cancer Research : MCR·Ahmed BasudanSteffi Oesterreich
Apr 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey S RossPhilip J Stephens
Sep 1, 2019·Molecular & Cellular Proteomics : MCP·Pamela WuJianjiong Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.