Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage

Molecular Medicine Reports
Bingjie ZhengShiguang Zhao

Abstract

Subarachnoid hemorrhage (SAH) is an important cause of mortality in stroke patients. Long non-coding RNAs (LncRNAs) have important functions in brain disease, however their expression profiles in SAH remain to be elucidated. The present study aimed to investigate the expression signatures of LncRNAs and mRNAs in early brain injury (EBI) following SAH in a rat model. Male Wistar rats were randomly divided into an SAH group and a sham operation group. The expression signatures of the LncRNAs and mRNAs in the temporal lobe cortex were investigated using a rat LncRNAs array following experimental SAH. The results revealed that there were 144 downregulated and 64 upregulated LncRNAs and 181 downregulated and 221 upregulated mRNAs following SAH. Additionally, two upregulated (BC092207, MRuc008hvl) and three downregulated (XR_006756, MRAK038897, MRAK017168) LncRNAs were confirmed using reverse transcription quantitative polymerase chain reaction. The differentially expressed mRNAs were further analyzed using the Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. The pathway analysis results provided by the KEGG database indicated that eight pathways associated with inflammation were involved in EBI followi...Continue Reading

References

Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Changman ZhouJohn H Zhang
Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Julian CahillJohn H Zhang
Jun 9, 2006·Neurological Research·Robert P OstrowskiJohn H Zhang
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tim R MercerJohn S Mattick
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Julian Cahill, John H Zhang
May 23, 2009·Stroke; a Journal of Cerebral Circulation·Takumi SozenJohn H Zhang
May 26, 2009·Expert Opinion on Biological Therapy·Deirdre M O'Connor, Timothy O'Brien
Apr 13, 2010·Brain Research·Irfan A QureshiMark F Mehler
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
Apr 21, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yong JiangJian-Guo Shi
Apr 27, 2012·Journal of Physiology and Biochemistry·Yong HuangQuan Zou
Aug 25, 2012·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Sherry H-Y ChouMingMing Ning
Sep 6, 2012·Stroke; a Journal of Cerebral Circulation·Ashutosh DharapRaghu Vemuganti
Oct 12, 2012·Molecular Neurobiology·Lin TanLan Tan
Mar 8, 2013·Biochemical and Biophysical Research Communications·Jin-Ping LiTao Xiao
Apr 9, 2013·Trends in Genetics : TIG·Shi-Yan NgLawrence W Stanton
May 22, 2013·Medical Hypotheses·Yuanzhao SunDai Zhou
Jul 3, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Irfan A Qureshi, Mark F Mehler
Nov 1, 2013·Nature Reviews. Drug Discovery·Hui LingGeorge A Calin

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Citations

Jul 22, 2017·Translational Neuroscience·Fengzhen HuangXiaoxi Yao
Dec 21, 2018·Non-coding RNA·Antonio Salgado-SomozaYvan Devaux
Sep 27, 2019·Annals of Clinical and Translational Neurology·Jeong-Min KimKon Chu
Dec 16, 2019·Neurochemistry International·Mario J BertogliatRaghu Vemuganti

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Methods Mentioned

BETA
electrophoresis
Feature Extraction
PCR

Software Mentioned

R package ‘ pheatmap
GraphPad
Agilent Feature Extraction
GeneSpring GX
Prism5

Related Concepts

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