Expression study of GLUT4 translocation-related genes in a porcine pre-diabetic model

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Thea KristensenSusanna Cirera

Abstract

Obesity is a world-wide exponentially growing health problem that increases the risk of co-morbidities including metabolic syndrome, pre-diabetes, Type 2 Diabetes Mellitus (T2DM), and cancer. These co-morbidities are all complex conditions constituting a big challenge when searching for susceptibility genes. Identification of relevant genes, which could contribute to an earlier identification of individuals prone to develop diabetes, is urgently needed as many long-term complications can be avoided by preventive measures. Pre-diabetes is mainly associated with hyperglycemia; thus studying this phenotype might provide knowledge on relevant genes implicated in molecular mechanisms underlying pre-diabetes, and contributing to the development of T2DM. In the present study, two groups of pigs with high (HGG, N=6) and low (NGG, N=6) fasting plasma glucose level respectively were selected from a large pig population. Transcriptional levels of seven genes involved in the glucose transporter 4 (GLUT4) translocation pathway were studied by quantitative real-time PCR (qPCR) in diabetes relevant tissues (pancreas, adipose tissue, skeletal muscle, liver and kidney). Three of the genes, TBC (Tre-2, BUB2, CDC16) 1 Domain Family Member 4 (TBC1...Continue Reading

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Nov 20, 2013·BMC Research Notes·Susanna Cirera

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Citations

Jun 1, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Susanna CireraKerstin Skovgaard
Sep 16, 2017·Molecular Genetics and Genomics : MGG·Caroline M Junker MentzelMerete Fredholm
Apr 12, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Caroline M Junker MentzelSusanna Cirera
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Chao ZhaoHui Cao

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