Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair

Laboratory Investigation; a Journal of Technical Methods and Pathology
H KämpferS Frank

Abstract

It has become evident that a closely regulated presence of vascular endothelial growth factor (VEGF) and angiopoietin (Ang) factors determines the fate of blood vessel formation during angiogenesis. As angiogenesis is central to a normal wound-healing process, we investigated the regulation of Ang-1 and -2 and the related tyrosine kinase with immunoglobulin and epidermal growth factor homology (Tie)-1 and -2 receptors during normal repair in Balb/c mice and diabetes-impaired wound healing conditions in genetically diabetic (db/db) mice. For both normal and impaired healing conditions, we observed a constitutive expression of Ang-1, which was paralleled by an increase of Ang-2 upon injury. Whereas the observed Ang-2 expression declines from Day 7 after injury in control mice, diabetic-impaired healing was characterized by still increasing amounts of Ang-2 at these time points. Furthermore, Tie-1 was strongly induced during repair with a prolonged expression in diabetic mice, whereas Tie-2 expression was constitutive during normal repair but completely absent in diabetes-impaired healing. The overexpression of Ang-2 in the presence of markedly reduced VEGF in wounds of diabetic mice was associated with a dramatic decrease in endo...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S WernerL T Williams
Jan 1, 1982·Diabetes·D L Coleman
May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D J DumontM L Breitman
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N SatoK L Audus
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y Xie, W A Muller
Feb 15, 1996·Nature·G H LeeJ M Friedman
Apr 17, 1997·Nature·W Risau
Oct 7, 1997·Circulation Research·A L WongK G Peters
Jan 24, 1998·The Journal of Biological Chemistry·R L LeibelS C Chua
Oct 17, 1998·Science·C SuriG D Yancopoulos
Feb 23, 1999·The American Journal of Pathology·A RivardJ M Isner
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M ValenzuelaG D Yancopoulos

❮ Previous
Next ❯

Citations

Apr 28, 2004·World Journal of Gastroenterology : WJG·Xiao-Dong SunJun-Da Li
Jul 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rania HarfoucheSabah N A Hussain
Mar 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chung-Hyun ChoGou Young Koh
Sep 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christian SchaeferNils Hansen-Algenstaedt
Jan 25, 2012·PloS One·Sophie CalderariEtienne Larger
Jul 24, 2012·Endocrine·Sazan RasulAlexandra Kautzky-Willer
Dec 13, 2012·Archives of Dermatological Research·Shinji NodaShinichi Sato
Mar 27, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·B KurtI Özaydın
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·S LoukovaaraR J Kaaja
Jun 29, 2007·International Journal of Cancer. Journal International Du Cancer·Brandt WhitehurstSophia Ran
Apr 17, 2007·Molecular and Cellular Biochemistry·Akira Wagatsuma
Jul 17, 2010·The British Journal of Dermatology·C A StatonN J Brown
Apr 16, 2013·BioMed Research International·Mei YangQingfeng Li
May 27, 2015·Advanced Healthcare Materials·Alexandra LisovskyMichael Vivian Sefton
Oct 26, 2016·Current Diabetes Reports·Peter A Campochiaro, Kevin G Peters
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
May 4, 2005·The International Journal of Lower Extremity Wounds·David O Bates, Rowan O Pritchard Jones
Mar 31, 2007·Journal of Leukocyte Biology·Louise BezuidenhoutNeil Davies
Sep 29, 2004·Microscopy Research and Technique·Rui-Cheng JiSeiji Kato
Apr 16, 2009·Acta Diabetologica·Christian SchaeferNils Hansen-Algenstaedt
Feb 28, 2014·American Journal of Physiology. Cell Physiology·Abdul Q SheikhDaria A Narmoneva
Jun 1, 2008·Annals of Dermatology·Yoon Young KimYoung Min Park
Jan 25, 2017·International Journal of Molecular Sciences·Meenakshi GaurVictoria V Lunyak
Sep 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Debanjan ChakrobortyChandrani Sarkar
Oct 23, 2008·Tissue Engineering. Part a·Paul Van SlykeDan Dumont
Jun 11, 2010·European Journal of Clinical Investigation·Himadri RoySeppo Ylä-Herttuala

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.