PMID: 7538603Jun 1, 1995Paper

Expressions of E-cadherin and exon v6-containing isoforms of CD44 and their prognostic values in human transitional cell carcinoma

The Journal of Urology
R L HongW J Lee

Abstract

Cell surface adhesion molecules, E-cadherin and exon v6 containing CD44 isoforms (CD44v6), were readily found in well-to-moderately differentiated urothelial cell lines but were down-regulated in poorly differentiated cell lines. One hundred and fifteen tumors of transitional cell carcinoma (TCC) were examined with E-cadherin and CD44v6 specific antibodies. Sixty-five (56.5%) tumors exhibited a preserved type while 50 (43.5%) showed a reduced type for CD44v6. Sixty-seven (58.3%) tumors were classified as the preserved type, and 48 (41.7%) were classified as the reduced type for E-cadherin. The staining pattern of E-cadherin was the same as that of CD44v6 in 87.0% (100 of 115) of tumors. The frequency of the reduced type was higher in poorly differentiated carcinomas (32 of 52 for CD44v6, p = 0.001; 27 of 52 for E-cadherin, p = 0.112) and tumors with an invasive growth pattern (22 of 27 for CD44v6, p < 0.001; 20 of 27 for E-cadherin, p < 0.001) than it was in well-differentiated carcinomas and tumors with expansile growth. However, the association with lymph node involvement or distant metastasis did not reach statistical significance. There was no difference in survival in reference to the expression patterns of CD44v6 and E-ca...Continue Reading

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Citations

Mar 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·X Garcia del MuroJ R Germà
Oct 19, 1999·Journal of Pediatric Hematology/oncology·M TakeuchiM Mayumi
Apr 21, 2010·The Journal of Urology·Tobias KlatteAllan J Pantuck
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei-Chun WengYing-Erh Chou
Dec 18, 2002·Critical Reviews in Clinical Laboratory Sciences·David NaorYoram Faitelson
Jul 20, 2002·The Journal of Urology·Mazen A GhanemRien J M Nijman
Apr 13, 2006·Virchows Archiv : an International Journal of Pathology·Yasuyoshi MiyataHiroshi Kanetake
May 9, 2012·Ultrastructural Pathology·Ola M Omran, Hesham S Ata

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