Expressions of Eotaxin-3, Interleukin-5, and Eosinophil-Derived Neurotoxin in Chronic Subdural Hematoma Fluids

Journal of Neurotrauma
Reo KawaguchiMasakazu Takayasu

Abstract

Eosinophils induce inflammation by releasing cytokines and cytotoxic granule proteins. Infiltration of eosinophilic granulocytes occurs in the outer membrane of chronic subdural hematomas (CSDHs). Eosinophils play an important role in the growth of CSDHs. However, the manner in which eosinophils accumulate within CSDH fluid remains undetermined. In the current study, we assessed the expression of eosinophil chemoattractants in CSDH fluids according to growth stage of CSDHs and examined the correlation between the two. CSDH fluids were obtained from 38 patients during trepanation surgery. Ecalectin, eotaxin-3, interleukin-5 (IL-5), and eosinophil-derived neurotoxin (EDN) concentrations were measured using enzyme-linked immunosorbent assay kits. For use as controls, serum samples were collected from 5 healthy adults, and cerebrospinal fluid (CSF) samples were collected from 5 adults with unruptured aneurysms. The percentage of eosinophils (%eosinophil) in CSDH fluids was calculated using Giemsa staining. Concentrations of ecalectin, eotaxin-3, IL-5, and EDN were nearly equivalent in serum and CSF samples; however, their concentrations were high in CSDH fluids. In particular, ecalectin and EDN levels in CSDH fluids were significan...Continue Reading

References

May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Jan 1, 1990·Neurosurgical Review·W Müller, R Firsching
Apr 1, 1989·European Journal of Immunology·J M WangA Mantovani
Feb 1, 1985·Journal of Neurosurgery·T YamashimaS Yamamoto
Mar 1, 1995·The Journal of Experimental Medicine·M E RothenbergP Leder
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·M HumbertS R Durham
Jun 27, 2000·International Archives of Allergy and Immunology·M Hirashima
Oct 17, 2002·Acta neurochirurgica·C SarkarV S Mehta
Apr 13, 2005·Trends in Molecular Medicine·A Barry Kay
Nov 26, 2005·Acta Oto-laryngologica·Y IinoS Kanegasaki
Feb 3, 2006·The Journal of Clinical Investigation·Carine BlanchardMarc E Rothenberg
Oct 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael R KonikoffMarc E Rothenberg
May 21, 2010·International Archives of Allergy and Immunology·Shigeki KatohMitsuomi Hirashima
Feb 12, 2011·Journal of Neurotrauma·Mikiko FunaiMasakazu Takayasu
Jun 2, 2012·Acta neurochirurgica·Kyu-Hyon ChonHa-Young Choi
Nov 24, 2012·Neuroscience Letters·Koji OsukaMasakazu Takayasu
Sep 3, 2013·European Respiratory Review : an Official Journal of the European Respiratory Society·Gilles GarciaMarc Humbert
Dec 17, 2014·Journal of Neurotrauma·Masahiro AoyamaMasakazu Takayasu
Oct 31, 2015·Journal of Neurosurgery·Ken TakizawaMitsunori Matsumae
Jun 23, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Chang-Keun KimEunmi Kwon
Jul 1, 2017·Journal of Neurotrauma·Koji OsukaMasakazu Takayasu
Sep 4, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hwan Soo KimJin Tack Kim
Oct 12, 2017·Radiology·Seung Pil BanChang Wan Oh

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Citations

Feb 16, 2020·Acta Neuropathologica Communications·Xuanhui LiuRongcai Jiang

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Methods Mentioned

BETA
bronchoalveolar lavage
biopsies

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