Exsudative AMD: Regression analysis of transpupillary thermotherapy with and without intravitreal injection of triamcinolone, bevacizumab and ranibizumab

Klinische Monatsblätter für Augenheilkunde
U Weber

Abstract

The aim of this study was to evaluate therapies for exsudative age-related macular degeneration (AMD) in a regression analysis. Transpupillary thermotherapy (TTT) with and without intravitreal injection (IVI) of triamcinolone, IVI of bevacizumab, and ranibizumab was investigated. 413 patients with an at least 6-month control were included in this retrospective single-centre study. 209 patients were treated with TTT, 36 received TTT with IVI of triamcinolone, and 70 avastin. All subjects underwent a full ophthalmological examination including fluorescein angiography (FA) at baseline and after 1, 3 and every 6 months. All patients were re-treated immediately after FA if necessary using the same method with ophthalmological controls starting again one month after therapy. 98 patients were treated with IVI of Lucentis. Lucentis patients received an upload with three injections and entered the examination protocol thereafter. Taking into account the natural course of exsudative AMD, therapies started at an advanced stage of the disease. Main outcome measures were best corrected visual acuity (log MAR), mean defect (MD), and pattern standard deviation (PSD) in a 10° visual field threshold test. The time-dependent course was estimated...Continue Reading

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