Extemporaneous benznidazole oral suspension prepared from commercially available tablets for treatment of Chagas disease in paediatric patients

Tropical Medicine & International Health : TM & IH
Mónica C GarcíaAlvaro F Jimenez-Kairuz

Abstract

To develop an extemporaneous 1% benznidazole (BNZ) suspension, with masked taste and adequate stability starting from available commercial tablets. The quality of compounding was evaluated through content uniformity measurement and physical and microbiological stability evaluation, under different storage conditions during 90 days. Six batches of 1% BNZ suspension were prepared using safe excipients currently available in a galenic area of Hospital Pharmacy and then stored at 5 and 25 °C for 90 days. The BNZ content was determined by UV spectrophotometry. Physical stability was defined as the absence of colour, odour and/or flavour changes and the re-suspension of solid phase by a reasonable amount of simple 15-s shaking. The compliance with microbiological attributes of non-sterile pharmaceutical products was also evaluated. An oral liquid suspension, containing 1% of BNZ, was developed from commercially available BNZ tablets. The formulations stored for 90 days were easily re-dispersed after a simple 15-s shaking, ensuring the pouring of a liquid volume containing the desired dose of BNZ. All samples were within the acceptable range of BNZ concentration with minimal standard deviations. There were no detectable changes in col...Continue Reading

References

Dec 21, 2000·Parasitology Today·C M Morel
Nov 16, 2002·International Journal of Pharmaceutics·M J MorillaE L Romero
Jun 3, 2005·Pediatrics·Olga Sánchez NegretteMiguel Angel Basombrío
Jul 16, 2005·Memórias do Instituto Oswaldo Cruz·Maria Jose MorillaEder Lilia Romero
Nov 18, 2005·PLoS Medicine·Sergio Sosa-EstaniAldofo Rubinstein
Nov 19, 2005·International Journal of Pharmaceutics·María C LamasClaudio J Salomón
Dec 13, 2005·Pharmacy World & Science : PWS·Vincent W Yeung, Ian C K Wong
Jun 20, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qun ShaoPeter York
Jun 27, 2006·Trends in Parasitology·Dirk Engels, Lorenzo Savioli
Jul 8, 2009·PLoS Neglected Tropical Diseases·Isabela RibeiroBernard Pecoul
Nov 28, 2009·Advanced Drug Delivery Reviews·Eder Lilia Romero, Maria Jose Morilla
Apr 27, 2010·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·F BuontempoD A Chiappetta
Jan 19, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Valentina FabianoGian Vincenzo Zuccotti
Sep 15, 2012·Parasitology International·Romina ManarinClaudio J Salomón

❮ Previous
Next ❯

Citations

Nov 22, 2015·Journal of Tropical Pediatrics·Quique Bassat
Sep 26, 2017·Tropical Medicine & International Health : TM & IH·Higo Fernando Santos SouzaClaudio Javier Salomon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.