Extemporaneously preparative biodegradable injectable polymer systems exhibiting temperature-responsive irreversible gelation

Journal of Biomaterials Science. Polymer Edition
Yasuyuki YoshidaYuichi Ohya

Abstract

On clinical application of biodegradable injectable polymer (IP) systems, quick extemporaneous preparation of IP formulations and longer duration time gel state after injection into the body are the important targets to be developed. Previously, we had reported temperature-responsive covalent gelation systems via bio-orthogonal thiol-ene reaction by 'mixing strategy' of amphiphilic biodegradable tri-block copolymer (tri-PCG) attaching acryloyl groups on both termini (tri-PCG-Acryl) with reactive polythiol. In other previous works, we found 'freeze-dry with PEG/dispersion' method as quick extemporaneous preparation method of biodegradable IP formulations. In this study, we applied this quick preparative method to the temperature-triggered covalent gelation system. The instant formulation (D-sample) could be prepared by 'freeze-dry with PEG/dispersion' just mixing of tri-PCG-Acryl micelle dispersion and tri-PCG/DPMP micelle dispersion with PEG, that can be prepared in 30 s from the dried samples. The obtained D-sample showed irreversible gelation and long duration time of gel state, which was basically the same as the formulations prepared by the usual heating dissolution method (S-sample). Interestingly, the D-sample could maint...Continue Reading

References

Mar 15, 2005·Biomacromolecules·Min Ji HwangByeongmoon Jeong
Jul 24, 2008·Chemical Society Reviews·Lin Yu, Jiandong Ding
Feb 19, 2010·Angewandte Chemie·Charles E Hoyle, Christopher N Bowman
Mar 3, 2010·Macromolecular Bioscience·Minh Khanh Nguyen, Doo Sung Lee
Oct 14, 2011·Accounts of Chemical Research·Min Hee ParkByeongmoon Jeong
Jun 13, 2012·Chemical Society Reviews·Hyo Jung MoonByeongmoon Jeong

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Methods Mentioned

BETA
nuclear magnetic resonance
size exclusion chromatography
size-exclusion chromatography
polymer exchange

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